Lgals3 lectin, galactose binding, soluble 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgals3provided by MGI
Official Full Name: lectin, galactose binding, soluble 3provided by MGI
Primary source: MGI:MGI:96778
See related: Ensembl:ENSMUSG00000050335 AllianceGenome:MGI:96778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GBP; L-34; gal3; Mac-2
Summary: Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 931.1), duodenum adult (RPKM 311.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (47611317..47623624)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (47373860..47386167)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel pathogenic role for galectin-3 in early disease stages of arrhythmogenic cardiomyopathy.
Title: Novel pathogenic role for galectin-3 in early disease stages of arrhythmogenic cardiomyopathy.
Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn.
Title: Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn.
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.
Title: Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.
Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases.
Title: Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases.
Transcriptional upregulation of galectin-3 in multiple sclerosis.
Title: Transcriptional upregulation of galectin-3 in multiple sclerosis.
Galectin-3 contributes to acute cardiac dysfunction and toxicity by increasing oxidative stress and fibrosis in doxorubicin-treated mice.
Title: Galectin-3 contributes to acute cardiac dysfunction and toxicity by increasing oxidative stress and fibrosis in doxorubicin-treated mice.
Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1.
Title: Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1.
Co-expression of galectin-3 and vimentin in triple negative breast cancer cells promotes tumor progression, metastasis and survival.
Title: Co-expression of galectin-3 and vimentin in triple negative breast cancer cells promotes tumor progression, metastasis and survival.
Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease.
Title: Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease.
Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration.
Title: Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration.

Submit: New GeneRIF Correction See all GeneRIFs (284)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127694 (e-PCR)
- UniSTS:211004

Lgals3 (e-PCR), detects polymorphism
- UniSTS:470617

RH69146 (e-PCR)
- UniSTS:42649

PMC263848P1 (e-PCR)
- UniSTS:272333

PMC263848P2 (e-PCR)
- UniSTS:272334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables IgE binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgE binding	ISO Inferred from Sequence Orthology more info
enables advanced glycation end-product receptor activity	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables disaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables disaccharide binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
NOT involved_in maintenance of protein location	IDA Inferred from Direct Assay more info	PubMed
involved_in monocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in immunological synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-3

Names: 35 kDa lectin; CBP 35; L-34 galactoside-binding lectin; carbohydrate-binding protein 35; gal-3; galactose-specific lectin 3; igE-binding protein; laminin-binding protein; lectin L-29; mac-2 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145953.1 → NP_001139425.1 galectin-3

See identical proteins and their annotated locations for NP_001139425.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC123665, AK149783, BY440035

Consensus CDS

CCDS26986.1

UniProtKB/Swiss-Prot

P16110

UniProtKB/TrEMBL

Q8C253

Related

ENSMUSP00000114350.2, ENSMUST00000150290.9

Conserved Domains (2) summary

smart00908
Location:137 → 258

Gal-bind_lectin; Galactoside-binding lectin

pfam02084
Location:18 → 110

Bindin; Bindin
NM_010705.3 → NP_034835.1 galectin-3

See identical proteins and their annotated locations for NP_034835.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK149783, BB853044, BY440035

Consensus CDS

CCDS26986.1

UniProtKB/Swiss-Prot

P16110

UniProtKB/TrEMBL

Q8C253

Related

ENSMUSP00000118169.2, ENSMUST00000142734.8

Conserved Domains (2) summary

smart00908
Location:137 → 258

Gal-bind_lectin; Galactoside-binding lectin

pfam02084
Location:18 → 110

Bindin; Bindin