Cytip cytohesin 1 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cytipprovided by MGI
Official Full Name: cytohesin 1 interacting proteinprovided by MGI
Primary source: MGI:MGI:2183535
See related: Ensembl:ENSMUSG00000026832 AllianceGenome:MGI:2183535
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbp; Cybr; Pscdbp; A130053M09Rik
Summary: Predicted to be involved in regulation of cell adhesion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cell cortex. Is expressed in metanephros. Orthologous to human CYTIP (cytohesin 1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 15.2), spleen adult (RPKM 14.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 33.05 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (58019151..58085559, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (58129139..58195549, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest a suppressive function for Cytip in mouse dendritic cells in limiting immune responses.
Title: Cytip regulates dendritic-cell function in contact hypersensitivity.
Cybr represses the expression of T-bet and IFN-gamma via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice.
Title: Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and host immunity.
These data suggest that Cybr is not absolutely required for hematopoietic cell development or function, but stem cells lacking Cybr are at a developmental disadvantage compared to wild-type cells.
Title: Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.
expression in vivo is differentially modulated by type 1 cytokines during lymphocyte maturation
Title: The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

General gene information

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Markers

AI462064 (e-PCR)
- UniSTS:178627

RH126974 (e-PCR)
- UniSTS:207333

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytohesin-interacting protein

Names: cbp HE; cytohesin binding protein; cytohesin-binding protein HE; pleckstrin homology, Sec7 and coiled-coil domains, binding protein; tamalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139200.4 → NP_631939.1 cytohesin-interacting protein

See identical proteins and their annotated locations for NP_631939.1

Status: VALIDATED

Source sequence(s)

AK152784, AK157859, AL928564

Consensus CDS

CCDS16048.1

UniProtKB/Swiss-Prot

A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9

UniProtKB/TrEMBL

Q3TCC3, Q3TLX8

Related

ENSMUSP00000028175.7, ENSMUST00000028175.7

Conserved Domains (1) summary

cd00992
Location:76 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

58019151..58085559 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498012.5 → XP_006498075.1 cytohesin-interacting protein isoform X1

See identical proteins and their annotated locations for XP_006498075.1

UniProtKB/Swiss-Prot

A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9

UniProtKB/TrEMBL

Q3TCC3, Q3TLX8

Conserved Domains (1) summary

cd00992
Location:76 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006498013.3 → XP_006498076.1 cytohesin-interacting protein isoform X1

See identical proteins and their annotated locations for XP_006498076.1

UniProtKB/Swiss-Prot

A2AS77, Q3TZH1, Q8R4T4, Q91VY6, Q9QZA9

UniProtKB/TrEMBL

Q3TCC3, Q3TLX8

Conserved Domains (1) summary

cd00992
Location:76 → 161

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...