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    DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 [ Homo sapiens (human) ]

    Gene ID: 8798, updated on 25-Jan-2022

    Summary

    Official Symbol
    DYRK4provided by HGNC
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:3095
    See related
    Ensembl:ENSG00000010219 MIM:609181; AllianceGenome:HGNC:3095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DYRK4 in Genome Data Viewer
    Location:
    12p13.32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (4562208..4613875)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (4671374..4724468)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 4 Neighboring gene RAD51 associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 10040 Neighboring gene coiled-coil domain containing 181 pseudogene Neighboring gene H3K27me3-DHS negatively-acting regulatory element H3 Neighboring gene A-kinase anchoring protein 3 Neighboring gene RAB5A, member RAS oncogene family pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NDUFA9

    Homology

    Clone Names

    • FLJ18618

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 4
    Names
    dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4
    NP_001269214.1
    NP_001269215.1
    NP_001358230.1
    NP_001381708.1
    NP_001381709.1
    NP_003836.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282285.3NP_001269214.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC005832
      UniProtKB/TrEMBL
      D3JEN2
      Conserved Domains (1) summary
      cl21453
      Location:1114
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001282286.2NP_001269215.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3

      See identical proteins and their annotated locations for NP_001269215.1

      Status: REVIEWED

      Source sequence(s)
      AC005832
      UniProtKB/TrEMBL
      B4E1A4
      Related
      ENST00000545571.5
      Conserved Domains (1) summary
      cl21453
      Location:1114
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001371301.2NP_001358230.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005832
      Conserved Domains (1) summary
      cd14225
      Location:175515
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
    4. NM_001394779.1NP_001381708.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC005832
      Related
      ENSP00000439697.2, ENST00000543431.6
      Conserved Domains (1) summary
      cd14225
      Location:175515
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
    5. NM_001394780.1NP_001381709.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC005832
      Conserved Domains (1) summary
      cd14225
      Location:169509
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4
    6. NM_003845.3NP_003836.1  dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_003836.1

      Status: REVIEWED

      Source sequence(s)
      AC005832
      Consensus CDS
      CCDS8530.1
      UniProtKB/Swiss-Prot
      Q9NR20
      Related
      ENSP00000441755.1, ENST00000540757.6
      Conserved Domains (1) summary
      cd14225
      Location:60400
      PKc_DYRK4; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4

    RNA

    1. NR_104115.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in three exons and contains a 3' terminal exon that extends past a splice site that is used in variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC005832, DB082653, GU139746
      Related
      ENST00000536157.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      4562208..4613875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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