Format

Send to:

Choose Destination

Links from OMIM

    • Showing Current items.

    SDS serine dehydratase [ Homo sapiens (human) ]

    Gene ID: 10993, updated on 8-Jul-2021

    Summary

    Official Symbol
    SDSprovided by HGNC
    Official Full Name
    serine dehydrataseprovided by HGNC
    Primary source
    HGNC:HGNC:10691
    See related
    Ensembl:ENSG00000135094 MIM:182128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDH
    Summary
    This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SDS in Genome Data Viewer
    Location:
    12q24.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113392445..113403887, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113830250..113841692, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene uncharacterized LOC105369989 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase like Neighboring gene LIM homeobox 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-threonine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isoleucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pyruvate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in threonine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    L-serine dehydratase/L-threonine deaminase
    Names
    L-serine ammonia-lyase
    L-serine deaminase
    L-serine dehydratase
    L-threonine dehydratase
    TDH
    NP_006834.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006843.3NP_006834.2  L-serine dehydratase/L-threonine deaminase

      See identical proteins and their annotated locations for NP_006834.2

      Status: REVIEWED

      Source sequence(s)
      BC020750, BG534053, BG566257, BU740747, J05037
      Consensus CDS
      CCDS9169.1
      UniProtKB/Swiss-Prot
      P20132
      UniProtKB/TrEMBL
      Q8WW81
      Related
      ENSP00000257549.4, ENST00000257549.9
      Conserved Domains (2) summary
      cd06448
      Location:10320
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
      pfam00291
      Location:5304
      PALP; Pyridoxal-phosphate dependent enzyme

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      113392445..113403887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center