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    CCNY cyclin Y [ Homo sapiens (human) ]

    Gene ID: 219771, updated on 15-Jan-2022

    Summary

    Official Symbol
    CCNYprovided by HGNC
    Official Full Name
    cyclin Yprovided by HGNC
    Primary source
    HGNC:HGNC:23354
    See related
    Ensembl:ENSG00000108100 MIM:612786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCNX; CFP1; CBCP1; C10orf9
    Summary
    Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
    Expression
    Ubiquitous expression in testis (RPKM 35.4), brain (RPKM 17.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCNY in Genome Data Viewer
    Location:
    10p11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (35247025..35572667)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35535953..35861595)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene cAMP responsive element modulator Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene uncharacterized LOC107984220 Neighboring gene Sharpr-MPRA regulatory region 12265 Neighboring gene uncharacterized LOC107984221 Neighboring gene gap junction protein delta 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ95513

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-Y
    Names
    cyc-Y
    cyclin box protein 1
    cyclin fold protein 1
    cyclin-X
    cyclin-box carrying protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282852.2NP_001269781.1  cyclin-Y isoform 3

      See identical proteins and their annotated locations for NP_001269781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA476431, AF413522, AF465728, AL117336, AL121749, BC094815
      Consensus CDS
      CCDS60513.1
      UniProtKB/Swiss-Prot
      Q8ND76
      Related
      ENSP00000344275.5, ENST00000339497.7
      Conserved Domains (1) summary
      cd20540
      Location:141237
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
    2. NM_001282853.2NP_001269782.1  cyclin-Y isoform 2

      See identical proteins and their annotated locations for NP_001269782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA476431, AF413522, AL117336, AL121749, BC050310, BC094815
      Consensus CDS
      CCDS7190.1
      UniProtKB/Swiss-Prot
      Q8ND76
      Related
      ENSP00000265375.9, ENST00000265375.13
      Conserved Domains (1) summary
      cd20540
      Location:112208
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
    3. NM_001282854.2NP_001269783.1  cyclin-Y isoform 5

      See identical proteins and their annotated locations for NP_001269783.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA476431, AF413522, AK303283, AL117336, AL121749, BC094815
      UniProtKB/Swiss-Prot
      Q8ND76
      UniProtKB/TrEMBL
      B7Z8E4
      Conserved Domains (1) summary
      pfam00134
      Location:10132
      Cyclin_N; Cyclin, N-terminal domain
    4. NM_145012.6NP_659449.3  cyclin-Y isoform 1

      See identical proteins and their annotated locations for NP_659449.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA476431, AF413522, AL117336, AL121749, BC094815
      Consensus CDS
      CCDS7189.1
      UniProtKB/Swiss-Prot
      Q8ND76
      Related
      ENSP00000363836.4, ENST00000374704.8
      Conserved Domains (1) summary
      cd20540
      Location:166262
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
    5. NM_181698.4NP_859049.2  cyclin-Y isoform 2

      See identical proteins and their annotated locations for NP_859049.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA476431, AF429969, AK057280, AL121749
      Consensus CDS
      CCDS7190.1
      UniProtKB/Swiss-Prot
      Q8ND76
      Related
      ENSP00000363838.1, ENST00000374706.5
      Conserved Domains (1) summary
      cd20540
      Location:112208
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      35247025..35572667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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