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    Gzmb granzyme B [ Mus musculus (house mouse) ]

    Gene ID: 14939, updated on 25-Jan-2022

    Summary

    Official Symbol
    Gzmbprovided by MGI
    Official Full Name
    granzyme Bprovided by MGI
    Primary source
    MGI:MGI:109267
    See related
    Ensembl:ENSMUSG00000015437 AllianceGenome:MGI:109267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11
    Summary
    This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in large intestine adult (RPKM 11.7), small intestine adult (RPKM 4.9) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Gzmb in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56496293..56499791, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56258836..56262334, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56877693..56881097, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene granzyme C Neighboring gene predicted gene, 24118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene high mobility group protein B1 pseudogene Neighboring gene ATPase, H+/K+ transporting, nongastric, alpha polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytolytic granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytolytic granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    granzyme B(G,H)
    Names
    cytotoxic cell protease 1
    fragmentin-2
    NP_038570.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013542.3NP_038570.1  granzyme B(G,H) preproprotein

      See identical proteins and their annotated locations for NP_038570.1

      Status: REVIEWED

      Source sequence(s)
      AC091783, AK157856, BU758224, BY227723
      Consensus CDS
      CCDS27147.1
      UniProtKB/Swiss-Prot
      P04187
      UniProtKB/TrEMBL
      Q3TZH4
      Related
      ENSMUSP00000015581.5, ENSMUST00000015581.6
      Conserved Domains (2) summary
      smart00020
      Location:20240
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:21243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56496293..56499791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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