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    SCD stearoyl-CoA desaturase [ Homo sapiens (human) ]

    Gene ID: 6319, updated on 17-Jan-2022

    Summary

    Official Symbol
    SCDprovided by HGNC
    Official Full Name
    stearoyl-CoA desaturaseprovided by HGNC
    Primary source
    HGNC:HGNC:10571
    See related
    Ensembl:ENSG00000099194 MIM:604031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCD1; FADS5; SCDOS; hSCD1; MSTP008
    Summary
    This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in fat (RPKM 972.1), brain (RPKM 238.0) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SCD in Genome Data Viewer
    Location:
    10q24.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100347233..100364826)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102106990..102124583)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene Sharpr-MPRA regulatory region 15237 Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene uncharacterized LOC105378452 Neighboring gene Wnt family member 8B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Human metabolic individuality in biomedical and pharmaceutical research.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of stearoyl-CoA desaturase (delta-9-desaturase; SCD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA increases SCD mRNA expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in unsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    stearoyl-CoA desaturase
    Names
    acyl-CoA desaturase
    delta(9)-desaturase
    fatty acid desaturase
    predicted protein of HQ0998
    stearoyl-CoA desaturase (delta-9-desaturase)
    stearoyl-CoA desaturase opposite strand
    NP_005054.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005063.5NP_005054.3  stearoyl-CoA desaturase

      See identical proteins and their annotated locations for NP_005054.3

      Status: REVIEWED

      Source sequence(s)
      AI761929, AK312312, AL139819, BC062303
      Consensus CDS
      CCDS7493.1
      UniProtKB/Swiss-Prot
      O00767
      Related
      ENSP00000359380.2, ENST00000370355.3
      Conserved Domains (2) summary
      cd03505
      Location:100337
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:102306
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      100347233..100364826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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