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    Pknox1 Pbx/knotted 1 homeobox [ Mus musculus (house mouse) ]

    Gene ID: 18771, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pknox1provided by MGI
    Official Full Name
    Pbx/knotted 1 homeoboxprovided by MGI
    Primary source
    MGI:MGI:1201409
    See related
    Ensembl:ENSMUSG00000006705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PR; PREP1; D17Wsu76; D17Wsu76e
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.1), testis adult (RPKM 10.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pknox1 in Genome Data Viewer
    Location:
    17 B1; 17 16.78 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31783688..31826667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31564722..31607693)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (31701718..31744638)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit V3 Neighboring gene predicted gene, 50105 Neighboring gene cystathionine beta-synthase Neighboring gene ribosomal protein S2, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein PKNOX1
    Names
    PBX/knotted homeobox 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016670.3NP_057879.2  homeobox protein PKNOX1

      See identical proteins and their annotated locations for NP_057879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC166575, BC052701, BY769139
      Consensus CDS
      CCDS28608.1
      UniProtKB/Swiss-Prot
      O70477
      Related
      ENSMUSP00000094966.4, ENSMUST00000097352.11
      Conserved Domains (2) summary
      pfam05920
      Location:277316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. NR_027493.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. This exon creates an upstream ORF with a strong Kozak signal and the potential to encode a protein of 40 aa. This putative protein does not overlap the functional protein and is not supported by other proteins. Also, since this transcript is a candidate for nonsense-mediated decay (NMD), it is not thought to encode a protein.
      Source sequence(s)
      AC166575, AK134000, BY769139

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31783688..31826667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249590.2XP_030105450.1  homeobox protein PKNOX1 isoform X3

      Conserved Domains (2) summary
      pfam05920
      Location:275314
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    2. XM_006523857.5XP_006523920.1  homeobox protein PKNOX1 isoform X2

      See identical proteins and their annotated locations for XP_006523920.1

      Related
      ENSMUSP00000157748.2, ENSMUST00000237248.2
      Conserved Domains (2) summary
      pfam05920
      Location:276315
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    3. XM_030249591.2XP_030105451.1  homeobox protein PKNOX1 isoform X4

      Conserved Domains (2) summary
      pfam05920
      Location:274313
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    4. XM_036160407.1XP_036016300.1  homeobox protein PKNOX1 isoform X4

      Conserved Domains (2) summary
      pfam05920
      Location:274313
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    5. XM_006523854.4XP_006523917.1  homeobox protein PKNOX1 isoform X1

      See identical proteins and their annotated locations for XP_006523917.1

      UniProtKB/Swiss-Prot
      O70477
      Related
      ENSMUSP00000134852.2, ENSMUST00000175806.9
      Conserved Domains (2) summary
      pfam05920
      Location:277316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    6. XM_006523858.3XP_006523921.1  homeobox protein PKNOX1 isoform X3

      Conserved Domains (2) summary
      pfam05920
      Location:275314
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    7. XM_006523856.5XP_006523919.1  homeobox protein PKNOX1 isoform X2

      See identical proteins and their annotated locations for XP_006523919.1

      Conserved Domains (2) summary
      pfam05920
      Location:276315
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    8. XM_006523855.4XP_006523918.1  homeobox protein PKNOX1 isoform X1

      See identical proteins and their annotated locations for XP_006523918.1

      UniProtKB/Swiss-Prot
      O70477
      Conserved Domains (2) summary
      pfam05920
      Location:277316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
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