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    Scnn1b sodium channel, nonvoltage-gated 1 beta [ Mus musculus (house mouse) ]

    Gene ID: 20277, updated on 22-Aug-2021

    Summary

    Official Symbol
    Scnn1bprovided by MGI
    Official Full Name
    sodium channel, nonvoltage-gated 1 betaprovided by MGI
    Primary source
    MGI:MGI:104696
    See related
    Ensembl:ENSMUSG00000030873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in lung adult (RPKM 59.5), kidney adult (RPKM 28.0) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Scnn1b in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121464261..121517951)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121865038..121918728)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (129008625..129062030)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 31 Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene predicted gene, 36848 Neighboring gene component of oligomeric golgi complex 7 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ligand-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ligand-gated sodium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to ligand-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aldosterone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within artery smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to aldosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epithelial fluid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within leukocyte activation involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within leukocyte activation involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mucus secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organismal water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil activation involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil-mediated killing of bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil-mediated killing of bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to food IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within urea homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of sodium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amiloride-sensitive sodium channel subunit beta
    Names
    ENaC beta
    SCNEB
    beta-ENaC
    beta-NaCH
    epithelial Na(+) channel subunit beta
    nonvoltage-gated sodium channel 1 subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272023.1NP_001258952.1  amiloride-sensitive sodium channel subunit beta

      See identical proteins and their annotated locations for NP_001258952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF112186, AK036819, AK087055
      Consensus CDS
      CCDS21804.1
      UniProtKB/Swiss-Prot
      Q9WU38
      UniProtKB/TrEMBL
      A2RS45
      Conserved Domains (2) summary
      TIGR00859
      Location:21621
      ENaC; sodium channel transporter
      TIGR00867
      Location:29538
      deg-1; degenerin
    2. NM_011325.2NP_035455.1  amiloride-sensitive sodium channel subunit beta

      See identical proteins and their annotated locations for NP_035455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF112186, AK036819, AK087055
      Consensus CDS
      CCDS21804.1
      UniProtKB/Swiss-Prot
      Q9WU38
      UniProtKB/TrEMBL
      A2RS45
      Related
      ENSMUSP00000033161.6, ENSMUST00000033161.7
      Conserved Domains (2) summary
      TIGR00859
      Location:21621
      ENaC; sodium channel transporter
      TIGR00867
      Location:29538
      deg-1; degenerin

    RNA

    1. NR_073548.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF112186, AK036819, AK087055, AK164709
      Related
      ENSMUST00000205520.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      121464261..121517951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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