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    Atg7 autophagy related 7 [ Mus musculus (house mouse) ]

    Gene ID: 74244, updated on 20-Jul-2021

    Summary

    Official Symbol
    Atg7provided by MGI
    Official Full Name
    autophagy related 7provided by MGI
    Primary source
    MGI:MGI:1921494
    See related
    Ensembl:ENSMUSG00000030314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ap; Agp7; Apg7l; Atg7l; Gm21553; 1810013K23Rik
    Summary
    This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.1), testis adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atg7 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114620075..114837565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114643127..114860604)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (114593143..114809954)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38875 Neighboring gene histamine receptor H1 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene vestigial like family member 4 Neighboring gene predicted gene, 38876 Neighboring gene predicted gene, 52944

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Atg12 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Atg12 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Atg12 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables Atg8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Atg8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within amino acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hyperoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of histone H4-K16 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative stranded viral RNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein modification process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein modification by small protein conjugation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pyramidal neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme ATG7
    Names
    ATG12-activating enzyme E1 ATG7
    autophagy-related protein 7
    ubiquitin-activating enzyme E1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253717.2NP_001240646.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 1

      See identical proteins and their annotated locations for NP_001240646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS59697.1
      UniProtKB/Swiss-Prot
      Q9D906
      UniProtKB/TrEMBL
      A0A0A0MQN4, Q3TM87
      Related
      ENSMUSP00000133215.4, ENSMUST00000169310.10
      Conserved Domains (3) summary
      cd01486
      Location:396720
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:54740
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:52359
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_001253718.2NP_001240647.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

      See identical proteins and their annotated locations for NP_001240647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, resulting in initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS39598.1
      UniProtKB/Swiss-Prot
      Q9D906
      UniProtKB/TrEMBL
      Q3TM87
      Related
      ENSMUSP00000138137.2, ENSMUST00000182793.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    3. NM_001379130.1NP_001366059.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122843, AC149276, AC170088
      Conserved Domains (1) summary
      TIGR01381
      Location:27713
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    4. NM_028835.5NP_083111.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

      See identical proteins and their annotated locations for NP_083111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, resulting in the initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122843, AC149276, AC170088
      Consensus CDS
      CCDS39598.1
      UniProtKB/Swiss-Prot
      Q9D906
      UniProtKB/TrEMBL
      Q3TM87
      Related
      ENSMUSP00000032457.10, ENSMUST00000032457.17
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

    RNA

    1. NR_166516.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122843, AC149276, AC170088

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114620075..114837565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152367.1XP_036008260.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    2. XM_036152368.1XP_036008261.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Related
      ENSMUSP00000138779.2, ENSMUST00000182428.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    3. XM_036152370.1XP_036008263.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    4. XM_036152369.1XP_036008262.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Related
      ENSMUSP00000138651.2, ENSMUST00000182902.8
      Conserved Domains (1) summary
      TIGR01381
      Location:11697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
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