Syt7 synaptotagmin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Syt7provided by RGD
Official Full Name: synaptotagmin 7provided by RGD
Primary source: RGD:62013
See related: Ensembl:ENSRNOG00000026432 AllianceGenome:RGD:62013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SytVII
Summary: Enables several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and syntaxin binding activity. Involved in calcium ion regulated lysosome exocytosis; plasma membrane repair; and regulation of secretion by cell. Located in dense core granule; lysosome; and plasma membrane. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 127.1), Heart (RPKM 56.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216456148..216518718)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207031359..207093787)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226435816..226498008)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Title: Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
In somata of Purkinje neurons in the cerebellar cortex, both SYT7 (and SYNCRIP) were expressed and co-localized.
Title: Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in the rat brain and co-localize in Purkinje neurons.
The slowed endocytosis phenotype previously reported after syt1 loss of function can also be triggered by other manipulations that promote asynchronous release such as Sr(2+) substitution and complexin loss of function. The link between asynchronous release and slowed endocytosis was due to selective targeting of fused synaptic vesicles toward slow retrieval by the asynchronous release Ca(2+) sensor synaptotagmin-7.
Title: Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.
Syt7 modulates fusion pore expansion in large secretory organelles.
Title: Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation.
Immunocytochemistry in rat chromaffin cells indicated that Syt1 was localized in large dense-core vesicles and synaptic-like microvesicles, whereas Syt7 was the predominant isoform present in large dense-core vesicles.
Title: Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells.
The Syt7 C2B domain structure is very similar to that of the Syt1 C2B domain and contains three Ca2+-binding sites.
Title: Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Data show that Syt I produced more rapid dilation of fusion pores than syt VII or syt IX, consistent with its role in synchronous synaptic release.
Title: Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions.
Results suggest that Syt VII is the Ca(2+) sensor of DCV fusion machinery and is an essential factor for the establishment and maintenance of the pool size of releasable DCVs.
Title: Silence of Synaptotagmin VII inhibits release of dense core vesicles in PC12 cells.
SYTVII is expressed on insulin granules and only SYTVII alpha is implicated in exocytosis under physiological conditions
Title: Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.
Synaptotagmin VII functions as a high-affinity calcium sensor and is targeted to secretory organelles in rat tumor cells
Title: Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat293 (e-PCR), detects polymorphism
- UniSTS:227107

NoName (e-PCR)
- UniSTS:489540

Syt7 (e-PCR), detects polymorphism
- UniSTS:507266

BE115310 (e-PCR)
- UniSTS:261513

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion regulated lysosome exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion regulated lysosome exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
involved_in calcium ion-regulated exocytosis of neurotransmitter	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-dependent activation of synaptic vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of calcium ion	IC Inferred by Curator more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion-dependent exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucagon secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in short-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	HDA more info	PubMed

General protein information

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Preferred Names: synaptotagmin-7

Names: protein Syt7; synaptotagmin VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398614.1 → NP_001385543.1 synaptotagmin-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000031195.4, ENSRNOT00000036232.7

Conserved Domains (3) summary

cd08386
Location:419 → 543

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:551 → 686

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:106 → 311

PHA03307; transcriptional regulator ICP4; Provisional
NM_001398615.1 → NP_001385544.1 synaptotagmin-7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000031890.4, ENSRNOT00000035576.7

Conserved Domains (3) summary

cd08386
Location:375 → 499

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:507 → 642

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

PHA03307
Location:100 → 267

PHA03307; transcriptional regulator ICP4; Provisional
NM_001398616.1 → NP_001385545.1 synaptotagmin-7 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000032388.5, ENSRNOT00000036180.7

Conserved Domains (2) summary

cd08386
Location:343 → 467

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:475 → 610

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_001398617.1 → NP_001385546.1 synaptotagmin-7 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000031944.4, ENSRNOT00000036168.7

Conserved Domains (2) summary

cd08386
Location:299 → 423

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:431 → 566

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_001398618.1 → NP_001385547.1 synaptotagmin-7 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000049360.4, ENSRNOT00000047964.5

Conserved Domains (2) summary

cd08386
Location:255 → 379

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:387 → 522

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_001398620.1 → NP_001385549.1 synaptotagmin-7 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000031816.4, ENSRNOT00000036283.7

Conserved Domains (2) summary

cd08386
Location:252 → 376

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:384 → 519

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
NM_021659.3 → NP_067691.1 synaptotagmin-7 isoform 7

See identical proteins and their annotated locations for NP_067691.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

F1M262, Q62747, Q99J98, Q99P33, Q99P34, Q99P35, Q99P36, Q99P37, Q99P38

UniProtKB/TrEMBL

A6I025

Related

ENSRNOP00000040667.3, ENSRNOT00000048704.6

Conserved Domains (2) summary

cd08386
Location:135 → 259

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:267 → 402

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216456148..216518718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272250.1 → XP_063128320.1 synaptotagmin-7 isoform X1
XM_039088864.2 → XP_038944792.1 synaptotagmin-7 isoform X2

Conserved Domains (2) summary

cd08386
Location:296 → 420

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:428 → 563

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
XM_039088876.2 → XP_038944804.1 synaptotagmin-7 isoform X3

UniProtKB/TrEMBL

A0A8I6A1J0, A6I025

Related

ENSRNOP00000085392.1

Conserved Domains (2) summary

cd08386
Location:179 → 303

C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7

cd08405
Location:311 → 446

C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7