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    Treh trehalase (brush-border membrane glycoprotein) [ Mus musculus (house mouse) ]

    Gene ID: 58866, updated on 23-Jun-2021

    Summary

    Official Symbol
    Trehprovided by MGI
    Official Full Name
    trehalase (brush-border membrane glycoprotein)provided by MGI
    Primary source
    MGI:MGI:1926230
    See related
    Ensembl:ENSMUSG00000032098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210412M19Rik
    Summary
    This gene belongs to the alpha-glucosidase family, whose members encode enzymes that carry out hydrolysis of alpha-glucoside bonds of a variety of carbohydrates. The enzyme encoded by this gene uses the disaccharide trehalose as a highly specific substrate and converts it into two glucose molecules. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in duodenum adult (RPKM 127.9), small intestine adult (RPKM 63.2) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Treh in Genome Data Viewer
    Location:
    9; 9 A5.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44584530..44597602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44673233..44686305)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44481321..44494387)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene cDNA sequence BC049987 Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trehalose catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    trehalase
    Names
    alpha,alpha-trehalase
    alpha,alpha-trehalose glucohydrolase
    NP_001264776.1
    NP_001264780.1
    NP_067456.1
    XP_006510579.1
    XP_006510580.1
    XP_006510581.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277847.1NP_001264776.1  trehalase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site causing a frameshift in the 5' coding region, and lacks an alternate exon in the 5' coding region which corrects the frameshift, compared to variant 1. It encodes isoform 2, which is shorter and contains an alternate internal segment, compared to isoform 1.
      Source sequence(s)
      AC151971
      Consensus CDS
      CCDS72222.1
      UniProtKB/TrEMBL
      E9PYP7
      Related
      ENSMUSP00000071206.6, ENSMUST00000071219.12
      Conserved Domains (1) summary
      cl17346
      Location:138512
      Trehalase; Trehalase
    2. NM_001277851.1NP_001264780.1  trehalase isoform 3

      See identical proteins and their annotated locations for NP_001264780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an internal exon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC151971, AK002566, BX630594
      Conserved Domains (1) summary
      cl17346
      Location:108483
      Trehalase
    3. NM_021481.3NP_067456.1  trehalase isoform 1 precursor

      See identical proteins and their annotated locations for NP_067456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC151971, AK008912, BX630594
      Consensus CDS
      CCDS23117.1
      UniProtKB/Swiss-Prot
      Q9JLT2
      Related
      ENSMUSP00000034609.5, ENSMUST00000034609.11
      Conserved Domains (2) summary
      COG1626
      Location:19551
      TreA; Neutral trehalase [Carbohydrate transport and metabolism]
      pfam01204
      Location:43547
      Trehalase; Trehalase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44584530..44597602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510517.3XP_006510580.1  trehalase isoform X2

      See identical proteins and their annotated locations for XP_006510580.1

      Conserved Domains (1) summary
      cl17346
      Location:108483
      Trehalase
    2. XM_006510516.4XP_006510579.1  trehalase isoform X1

      See identical proteins and their annotated locations for XP_006510579.1

      Conserved Domains (1) summary
      pfam01204
      Location:3508
      Trehalase
    3. XM_006510518.4XP_006510581.1  trehalase isoform X2

      See identical proteins and their annotated locations for XP_006510581.1

      Conserved Domains (1) summary
      cl17346
      Location:108483
      Trehalase
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