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    CYP2F1 cytochrome P450 family 2 subfamily F member 1 [ Homo sapiens (human) ]

    Gene ID: 1572, updated on 25-Nov-2021

    Summary

    Official Symbol
    CYP2F1provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily F member 1provided by HGNC
    Primary source
    HGNC:HGNC:2632
    See related
    Ensembl:ENSG00000197446 MIM:124070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2F1; CYP2F; CYPIIF1
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See CYP2F1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41114292..41128381)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41620337..41634286)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily A member 13 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1789

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126121

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in naphthalene catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome P450 2F1
    Names
    cytochrome P450, family 2, subfamily F, polypeptide 1
    cytochrome P450, subfamily IIF, polypeptide 1
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    xenobiotic monooxygenase
    NP_000765.2
    XP_011524853.1
    XP_011524854.1
    XP_011524855.1
    XP_011524856.1
    XP_011524857.1
    XP_016881873.1
    XP_016881874.1
    XP_016881875.1
    XP_016881876.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007930.1 RefSeqGene

      Range
      4985..18934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000774.5NP_000765.2  cytochrome P450 2F1 precursor

      See identical proteins and their annotated locations for NP_000765.2

      Status: REVIEWED

      Source sequence(s)
      BC109057, CB853363, DC413790
      Consensus CDS
      CCDS12572.1
      UniProtKB/Swiss-Prot
      P24903
      Related
      ENSP00000333534.2, ENST00000331105.7
      Conserved Domains (1) summary
      pfam00067
      Location:31488
      p450; Cytochrome P450

    RNA

    1. NR_135528.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008962, AK316498, CB853363
      Related
      ENST00000532164.2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41114292..41128381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526552.3XP_011524854.1  cytochrome P450 2F1 isoform X3

      See identical proteins and their annotated locations for XP_011524854.1

      Conserved Domains (1) summary
      pfam00067
      Location:31432
      p450; Cytochrome P450
    2. XM_011526551.3XP_011524853.1  cytochrome P450 2F1 isoform X3

      See identical proteins and their annotated locations for XP_011524853.1

      Conserved Domains (1) summary
      pfam00067
      Location:31432
      p450; Cytochrome P450
    3. XM_011526554.3XP_011524856.1  cytochrome P450 2F1 isoform X5

      Conserved Domains (1) summary
      pfam00067
      Location:1368
      p450; Cytochrome P450
    4. XM_017026385.1XP_016881874.1  cytochrome P450 2F1 isoform X2

    5. XM_011526553.2XP_011524855.1  cytochrome P450 2F1 isoform X4

      Conserved Domains (1) summary
      pfam00067
      Location:106453
      p450; Cytochrome P450
    6. XM_017026387.1XP_016881876.1  cytochrome P450 2F1 isoform X7

    7. XM_017026384.2XP_016881873.1  cytochrome P450 2F1 isoform X1

    8. XM_017026386.1XP_016881875.1  cytochrome P450 2F1 isoform X7

    9. XM_011526555.3XP_011524857.1  cytochrome P450 2F1 isoform X6

      Conserved Domains (1) summary
      pfam00067
      Location:106377
      p450; Cytochrome P450

    RNA

    1. XR_935755.1 RNA Sequence

    2. XR_430190.3 RNA Sequence

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