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    Axin2 axin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29134, updated on 30-Sep-2021

    Summary

    Official Symbol
    Axin2provided by RGD
    Official Full Name
    axin 2provided by RGD
    Primary source
    RGD:69259
    See related
    EnsemblRapid:ENSRNOG00000055010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    axil; axin-2
    Summary
    inhibits axis formation; acts as a negative regulator of the Wnt signaling pathway by inducing GSK-3beta-dependent phosphorylation of beta-catenin [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 134.5), Thymus (RPKM 88.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Axin2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (93893830..93927042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97212483..97238824)

    Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112 Neighboring gene uncharacterized LOC120095198 Neighboring gene uncharacterized LOC120095199 Neighboring gene uncharacterized LOC108352227 Neighboring gene uncharacterized LOC120095200 Neighboring gene uncharacterized LOC102550112

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chondrocyte differentiation involved in endochondral bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intramembranous ossification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intramembranous ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of DNA repeat elements IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of DNA repeat elements ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centromeric sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of centromeric sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chondrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of chondrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secondary heart field specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within secondary heart field specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    axin-2
    Names
    axin-like protein
    axis inhibition protein 2
    conductin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024355.1NP_077331.1  axin-2

      See identical proteins and their annotated locations for NP_077331.1

      Status: PROVISIONAL

      Source sequence(s)
      AF017757
      UniProtKB/Swiss-Prot
      O70240
      Related
      ENSRNOP00000073088.2, ENSRNOT00000088599.2
      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

      Range
      93893830..93927042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085705.1XP_038941633.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. XM_039085702.1XP_038941630.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
    3. XM_039085700.1XP_038941628.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
    4. XM_039085701.1XP_038941629.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
    5. XM_039085704.1XP_038941632.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
    6. XM_039085703.1XP_038941631.1  axin-2 isoform X1

      Conserved Domains (4) summary
      cd08707
      Location:82198
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:756838
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1273
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam08833
      Location:433468
      Axin_b-cat_bind; Axin beta-catenin binding domain
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