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    Adar adenosine deaminase, RNA-specific [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81635, updated on 22-Aug-2021

    Summary

    Official Symbol
    Adarprovided by RGD
    Official Full Name
    adenosine deaminase, RNA-specificprovided by RGD
    Primary source
    RGD:71099
    See related
    Ensembl:ENSRNOG00000020744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    converts adenosine to inosine in double stranded RNA [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 163.5), Heart (RPKM 142.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adar in Genome Data Viewer
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175138391..175178280)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189045551..189085448)

    Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC120100866 Neighboring gene cholinergic receptor nicotinic beta 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine to inosine editing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within base conversion or substitution editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA loading onto RISC involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of RNA interference IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in somatic diversification of immune receptors via somatic mutation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somatic diversification of immune receptors via somatic mutation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of supraspliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of supraspliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    DRADA
    NP_112268.1
    XP_006232836.1
    XP_006232837.1
    XP_006232838.1
    XP_006232840.1
    XP_038959138.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031006.1NP_112268.1  double-stranded RNA-specific adenosine deaminase

      See identical proteins and their annotated locations for NP_112268.1

      Status: PROVISIONAL

      Source sequence(s)
      U18942
      UniProtKB/Swiss-Prot
      P55266
      Related
      ENSRNOP00000028181.2, ENSRNOT00000028181.5
      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7851168
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

      Range
      175138391..175178280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232775.4XP_006232837.1  double-stranded RNA-specific adenosine deaminase isoform X2

      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7671150
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    2. XM_039103210.1XP_038959138.1  double-stranded RNA-specific adenosine deaminase isoform X4

      Conserved Domains (6) summary
      smart00552
      Location:7541137
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:421491
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19915
      Location:640710
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cl00054
      Location:532602
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    3. XM_006232774.4XP_006232836.1  double-stranded RNA-specific adenosine deaminase isoform X1

      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7931176
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    4. XM_006232778.3XP_006232840.1  double-stranded RNA-specific adenosine deaminase isoform X5

      See identical proteins and their annotated locations for XP_006232840.1

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cl02659
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    5. XM_006232776.4XP_006232838.1  double-stranded RNA-specific adenosine deaminase isoform X3

      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7591142
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain
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