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    ADGRL4 adhesion G protein-coupled receptor L4 [ Homo sapiens (human) ]

    Gene ID: 64123, updated on 25-Jan-2022

    Summary

    Official Symbol
    ADGRL4provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor L4provided by HGNC
    Primary source
    HGNC:HGNC:20822
    See related
    Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETL; ELTD1; KPG_003
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
    Orthologs
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    Genomic context

    See ADGRL4 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (78889764..79006730, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79355449..79472415, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23 pseudogene 3 Neighboring gene SNW domain containing 1 pseudogene Neighboring gene VISTA enhancer hs1989 Neighboring gene phosphoserine aminotransferase 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor L4
    Names
    EGF, latrophilin and seven transmembrane domain containing 1
    EGF, latrophilin and seven transmembrane domain-containing protein 1
    EGF-TM7-latrophilin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022159.4NP_071442.2  adhesion G protein-coupled receptor L4 precursor

      See identical proteins and their annotated locations for NP_071442.2

      Status: VALIDATED

      Source sequence(s)
      AB032017, AC099674, AK129766, DA477962
      Consensus CDS
      CCDS41352.1
      UniProtKB/Swiss-Prot
      Q9HBW9
      Related
      ENSP00000359778.3, ENST00000370742.4
      Conserved Domains (4) summary
      pfam01825
      Location:368412
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:5891
      EGF_CA; Calcium-binding EGF domain
      pfam16489
      Location:139330
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:424660
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      78889764..79006730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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