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    Il12rb1 interleukin 12 receptor, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 16161, updated on 5-Jan-2022

    Summary

    Official Symbol
    Il12rb1provided by MGI
    Official Full Name
    interleukin 12 receptor, beta 1provided by MGI
    Primary source
    MGI:MGI:104579
    See related
    Ensembl:ENSMUSG00000000791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD212; IL-12R[b]
    Summary
    Contributes to cytokine binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in external side of plasma membrane. Part of interleukin-23 receptor complex. Is expressed in mandible; maxilla; orbito-sphenoid; rib; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in thymus adult (RPKM 9.3), spleen adult (RPKM 1.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il12rb1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.21 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71261005..71276186)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70808360..70823542)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73332348..73345323)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene microRNA 7240 Neighboring gene arrestin domain containing 2 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-12 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to interleukin-12 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-12 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to interleukin-23 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-23 binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to interleukin-23 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of interleukin-12 receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of interleukin-12 receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of interleukin-23 receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of interleukin-23 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of interleukin-23 receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-12 receptor subunit beta-1
    Names
    IL-12 receptor beta component
    IL-12 receptor subunit beta-1
    IL-12R subunit beta-1
    IL-12R-beta-1
    Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008353.2NP_032379.2  interleukin-12 receptor subunit beta-1 precursor

      See identical proteins and their annotated locations for NP_032379.2

      Status: VALIDATED

      Source sequence(s)
      AC162446, AK137577
      Consensus CDS
      CCDS22382.1
      UniProtKB/Swiss-Prot
      Q60837
      Related
      ENSMUSP00000000808.8, ENSMUST00000000808.8
      Conserved Domains (2) summary
      pfam00041
      Location:470553
      fn3; Fibronectin type III domain
      pfam02720
      Location:657714
      DUF222; Domain of unknown function (DUF222)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71261005..71276186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509557.4XP_006509620.1  interleukin-12 receptor subunit beta-1 isoform X1

      Conserved Domains (2) summary
      pfam00041
      Location:470553
      fn3; Fibronectin type III domain
      pfam02720
      Location:658715
      DUF222; Domain of unknown function (DUF222)
    2. XM_006509559.5XP_006509622.1  interleukin-12 receptor subunit beta-1 isoform X3

      Conserved Domains (1) summary
      pfam00041
      Location:470553
      fn3; Fibronectin type III domain
    3. XM_006509560.5XP_006509623.1  interleukin-12 receptor subunit beta-1 isoform X4

      UniProtKB/TrEMBL
      A0A1D5RL98
      Related
      ENSMUSP00000148279.2, ENSMUST00000212657.2
      Conserved Domains (1) summary
      pfam00041
      Location:470552
      fn3; Fibronectin type III domain
    4. XM_006509558.5XP_006509621.1  interleukin-12 receptor subunit beta-1 isoform X2

      Conserved Domains (2) summary
      pfam00041
      Location:449532
      fn3; Fibronectin type III domain
      pfam02720
      Location:637694
      DUF222; Domain of unknown function (DUF222)
    5. XM_006509561.5XP_006509624.1  interleukin-12 receptor subunit beta-1 isoform X5

      See identical proteins and their annotated locations for XP_006509624.1

      Conserved Domains (1) summary
      pfam00041
      Location:305388
      fn3; Fibronectin type III domain
    6. XM_011242266.4XP_011240568.1  interleukin-12 receptor subunit beta-1 isoform X5

      See identical proteins and their annotated locations for XP_011240568.1

      Conserved Domains (1) summary
      pfam00041
      Location:305388
      fn3; Fibronectin type III domain
    7. XM_006509562.4XP_006509625.1  interleukin-12 receptor subunit beta-1 isoform X6

      Conserved Domains (1) summary
      pfam00041
      Location:191274
      fn3; Fibronectin type III domain
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