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    F9 coagulation factor IX [ Sus scrofa (pig) ]

    Gene ID: 397518, updated on 5-Mar-2024

    Summary

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    Official Symbol
    F9provided by VGNC
    Official Full Name
    coagulation factor IXprovided by VGNC
    Primary source
    VGNC:VGNC:109453
    See related
    Ensembl:ENSSSCG00000012711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    FIXA
    Expression
    Biased expression in liver (RPKM 227.9), mixtures (RPKM 90.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (114218704..114250436)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (130417620..130448319)

    Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 13 Neighboring gene uncharacterized LOC110257819 Neighboring gene uncharacterized LOC110257820 Neighboring gene 40S ribosomal protein S27-like Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene ATPase phospholipid transporting 11C Neighboring gene microRNA mir-505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Detection of an MboI RFLP at the porcine clotting factor IX locus and verification of sex linkage. Signer EN, et al. Anim Genet, 1996 Apr. PMID 8856916
    2. X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Brandstetter H, et al. Proc Natl Acad Sci U S A, 1995 Oct 10. PMID 7568220, Free PMC Article
    3. Degradation of coagulation proteins by an enzyme from Malayan pit viper (Akistrodon rhodostoma) venom. Lollar P, et al. Biochemistry, 1987 Dec 1. PMID 3322404
    4. Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species. Sarkar G, et al. Genomics, 1990 Jan. PMID 2303254
    5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor IX
    Names
    christmas factor
    NP_001157475.1
    XP_020935171.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164003.1 → NP_001157475.1  coagulation factor IX

      Status: PROVISIONAL

      Source sequence(s)
      AK232625
      UniProtKB/TrEMBL
      A0A4X1SHD2, A0A8D0IL43, A0A8D1UGL1, F1RQ75
      Related
      ENSSSCP00000013514.3, ENSSSCT00000013897.5
      Conserved Domains (5) summary
      smart00020
      Location:227 → 455
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:28 → 92
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:93 → 129
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:228 → 458
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:134 → 170
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

      Range
      114218704..114250436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021079512.1 → XP_020935171.1  coagulation factor IX isoform X1

      UniProtKB/TrEMBL
      A0A287BHR3, A0A4X1SHU9, A0A8D0IQP7, A0A8D1UGE8
      Related
      ENSSSCP00000055678.1, ENSSSCT00000044683.3
      Conserved Domains (3) summary
      smart00069
      Location:28 → 92
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:93 → 129
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:185 → 415
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16293.2 GenPept UniProtKB/Swiss-Prot:P16293

    Gene LinkOut

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