Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    MYH10 myosin heavy chain 10 [ Homo sapiens (human) ]

    Gene ID: 4628, updated on 25-Nov-2021

    Summary

    Official Symbol
    MYH10provided by HGNC
    Official Full Name
    myosin heavy chain 10provided by HGNC
    Primary source
    HGNC:HGNC:7568
    See related
    Ensembl:ENSG00000133026 MIM:160776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMMHCB; NMMHC-IIB
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MYH10 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8474212..8631369, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8377530..8534043, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 4336 and 10869 Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene uncharacterized LOC107987245 Neighboring gene uncharacterized LOC112268195 Neighboring gene uncharacterized LOC102724262 Neighboring gene RNA, U7 small nuclear 43 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2377 Neighboring gene ribosomal protein S26 pseudogene 53 Neighboring gene peptidylprolyl isomerase A pseudogene 52 Neighboring gene Sharpr-MPRA regulatory region 9864 Neighboring gene uncharacterized LOC105371525 Neighboring gene VISTA enhancer hs2548

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-01-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, heavy chain 10, non-muscle (MYH10) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Tat tat The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells PubMed
    retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC134913, MGC134914

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to microfilament motor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myosin II filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    part_of polysome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin-10
    Names
    myosin heavy chain, nonmuscle type B
    myosin, heavy chain 10, non-muscle
    myosin, heavy polypeptide 10, non-muscle
    nonmuscle myosin II heavy chain-B
    nonmuscle myosin heavy chain IIB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042305.2 RefSeqGene

      Range
      5037..161538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256012.3NP_001242941.1  myosin-10 isoform 1

      See identical proteins and their annotated locations for NP_001242941.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS58515.1
      UniProtKB/Swiss-Prot
      P35580
      UniProtKB/TrEMBL
      G1UI33
      Related
      ENSP00000353590.4, ENST00000360416.8
      Conserved Domains (3) summary
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8791959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    2. NM_001256095.2NP_001243024.1  myosin-10 isoform 3

      See identical proteins and their annotated locations for NP_001243024.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS73984.1
      UniProtKB/Swiss-Prot
      P35580
      Related
      ENSP00000369315.5, ENST00000379980.8
      Conserved Domains (3) summary
      cd14920
      Location:99780
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8571937
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    3. NM_001375266.1NP_001362195.1  myosin-10 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011061, AC025518, AC026130
      Conserved Domains (3) summary
      cd14920
      Location:99781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8581938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    4. NM_005964.5NP_005955.3  myosin-10 isoform 2

      See identical proteins and their annotated locations for NP_005955.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC011061, AC025518, AC026130
      Consensus CDS
      CCDS11144.1
      UniProtKB/Swiss-Prot
      P35580
      Related
      ENSP00000269243.4, ENST00000269243.8
      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      8474212..8631369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523878.2XP_011522180.1  myosin-10 isoform X1

      Conserved Domains (11) summary
      COG5134
      Location:13781506
      COG5134; Uncharacterized conserved protein [Function unknown]
      cd14920
      Location:129811
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:117811
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8881968
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:64102
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16401650
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:10841173
      DUF342; Protein of unknown function (DUF342)
      cl19511
      Location:11511262
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16851736
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15441650
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:18131907
      DUF2570; Protein of unknown function (DUF2570)
    2. XM_017024680.1XP_016880169.1  myosin-10 isoform X5

      UniProtKB/Swiss-Prot
      P35580
      Conserved Domains (3) summary
      cd14920
      Location:99780
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8571937
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    3. XM_011523880.2XP_011522182.1  myosin-10 isoform X3

      Conserved Domains (11) summary
      COG5134
      Location:13681496
      COG5134; Uncharacterized conserved protein [Function unknown]
      cd14920
      Location:129801
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:117801
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8781958
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:64102
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16301640
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:10741163
      DUF342; Protein of unknown function (DUF342)
      cl19511
      Location:11411252
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16751726
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15341640
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:18031897
      DUF2570; Protein of unknown function (DUF2570)
    4. XM_011523879.2XP_011522181.1  myosin-10 isoform X2

      Conserved Domains (11) summary
      COG5134
      Location:13771505
      COG5134; Uncharacterized conserved protein [Function unknown]
      cd14920
      Location:129810
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:117810
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8871967
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:64102
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16391649
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:10831172
      DUF342; Protein of unknown function (DUF342)
      cl19511
      Location:11501261
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16841735
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15431649
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:18121906
      DUF2570; Protein of unknown function (DUF2570)
    5. XM_011523875.2XP_011522177.1  myosin-10 isoform X7

      Conserved Domains (11) summary
      COG5134
      Location:13991527
      COG5134; Uncharacterized conserved protein [Function unknown]
      cd14920
      Location:129832
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:117832
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:9091989
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:64102
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16611671
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:11051194
      DUF342; Protein of unknown function (DUF342)
      cl19511
      Location:11721283
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:17061757
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15651671
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:18341928
      DUF2570; Protein of unknown function (DUF2570)
    6. XM_017024681.1XP_016880170.1  myosin-10 isoform X6

      UniProtKB/Swiss-Prot
      P35580
      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    7. XM_017024678.1XP_016880167.1  myosin-10 isoform X4

      Conserved Domains (3) summary
      cd14920
      Location:99781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8581938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    8. XM_017024679.1XP_016880168.1  myosin-10 isoform X4

      Conserved Domains (3) summary
      cd14920
      Location:99781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8581938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    9. XM_017024682.1XP_016880171.1  myosin-10 isoform X6

      UniProtKB/Swiss-Prot
      P35580
      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    Support Center