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    Mtmr7 myotubularin related protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 54384, updated on 28-Oct-2021

    Summary

    Official Symbol
    Mtmr7provided by MGI
    Official Full Name
    myotubularin related protein 7provided by MGI
    Primary source
    MGI:MGI:1891693
    See related
    Ensembl:ENSMUSG00000039431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 9.0) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Mtmr7 in Genome Data Viewer
    Location:
    8; 8 A4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41003184..41088210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40548199..40634935, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (41635513..41720146, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene a disintegrin and metallopeptidase domain 24 (testase 1) Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol bisphosphate phosphatase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myotubularin-related protein 7
    Names
    inositol 1,3-bisphosphate phosphatase
    phosphatidylinositol-3-phosphate phosphatase
    NP_001035789.1
    XP_006509530.1
    XP_006509532.1
    XP_017168391.1
    XP_036010070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040699.1NP_001035789.1  myotubularin-related protein 7

      See identical proteins and their annotated locations for NP_001035789.1

      Status: VALIDATED

      Source sequence(s)
      AC158915, AK081973, BY741806
      Consensus CDS
      CCDS40324.1
      UniProtKB/Swiss-Prot
      Q9Z2C9
      Related
      ENSMUSP00000043851.11, ENSMUST00000048898.17
      Conserved Domains (2) summary
      cd13344
      Location:1103
      PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam06602
      Location:109446
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      41003184..41088210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154177.1XP_036010070.1  myotubularin-related protein 7 isoform X2

      Conserved Domains (1) summary
      cl28904
      Location:1212
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_017312902.3XP_017168391.1  myotubularin-related protein 7 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:1295
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_006509467.5XP_006509530.1  myotubularin-related protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006509530.1

      Conserved Domains (1) summary
      cl28904
      Location:1212
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    4. XM_006509469.5XP_006509532.1  myotubularin-related protein 7 isoform X3

      Conserved Domains (1) summary
      pfam06602
      Location:1151
      Myotub-related; Myotubularin-like phosphatase domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019433.1: Suppressed sequence

      Description
      NM_019433.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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