rnf175 ring finger protein 175 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rnf175provided by ZNC
Official Full Name: ring finger protein 175provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1104
See related: Ensembl:ENSDARG00000037647 AllianceGenome:ZFIN:ZDB-GENE-040426-1104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56665
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Orthologous to human RNF175 (ring finger protein 175). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (10037444..10048514, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (9353333..9364387, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING finger protein 175

Names: DKEYP-75B4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328343.1 → NP_001315272.1 RING finger protein 175 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BX548256

UniProtKB/TrEMBL

A0A8M1P4N4, F1QUH4

Related

ENSDARP00000108386.2, ENSDART00000125358.3

Conserved Domains (1) summary

pfam13639
Location:210 → 261

zf-RING_2; Ring finger domain
NM_200308.3 → NP_956602.2 RING finger protein 175 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon, resulting in the use of a downstream translational start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BX548256

UniProtKB/TrEMBL

A0A8M1PH01, B8A5M0

Related

ENSDARP00000054834.5, ENSDART00000054835.7

Conserved Domains (1) summary

pfam13639
Location:198 → 249

zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

10037444..10048514 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466728.1 → XP_021322403.1 RING finger protein 175 isoform X1

UniProtKB/TrEMBL

A0A8M9P7Z3

Conserved Domains (1) summary

cl17238
Location:210 → 239

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain