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    Calml4 calmodulin-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 75600, updated on 5-Jan-2022

    Summary

    Official Symbol
    Calml4provided by MGI
    Official Full Name
    calmodulin-like 4provided by MGI
    Primary source
    MGI:MGI:1922850
    See related
    Ensembl:ENSMUSG00000032246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010002G05Rik
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Is expressed in several structures, including 4th ventricle lateral recess; choroid invagination; ear; forelimb bud; and somite. Orthologous to human CALML4 (calmodulin like 4). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in kidney adult (RPKM 59.1), large intestine adult (RPKM 43.2) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Calml4 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62765068..62783203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62857472..62875921)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (62705911..62723725)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene fem 1 homolog b Neighboring gene ribsomal protein S2 pseudogene Neighboring gene ceroid-lipofuscinosis, neuronal 6 Neighboring gene protein inhibitor of activated STAT 1 Neighboring gene predicted gene, 35574 Neighboring gene predicted gene, 24526

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    calmodulin-like protein 4
    Names
    CALM-Rel
    calmodulin-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102468.1NP_001095938.1  calmodulin-like protein 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BY097052, CO039047
      Consensus CDS
      CCDS52827.1
      UniProtKB/TrEMBL
      E9Q1L1
      Related
      ENSMUSP00000132298.2, ENSMUST00000163820.3
      Conserved Domains (1) summary
      cl08302
      Location:47100
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_138304.2NP_612177.1  calmodulin-like protein 4 isoform a

      See identical proteins and their annotated locations for NP_612177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC164614
      Consensus CDS
      CCDS40664.1
      UniProtKB/Swiss-Prot
      Q91WQ9
      Related
      ENSMUSP00000034777.7, ENSMUST00000034777.14
      Conserved Domains (3) summary
      PTZ00184
      Location:1144
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:1274
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:94147
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      62765068..62783203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313679.3XP_017169168.1  calmodulin-like protein 4 isoform X3

      Conserved Domains (1) summary
      PTZ00184
      Location:3199
      PTZ00184; calmodulin; Provisional
    2. XM_006511529.5XP_006511592.1  calmodulin-like protein 4 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:25146
      PTZ00184; calmodulin; Provisional
    3. XM_006511532.2XP_006511595.1  calmodulin-like protein 4 isoform X4

      See identical proteins and their annotated locations for XP_006511595.1

      UniProtKB/Swiss-Prot
      Q91WQ9
      Related
      ENSMUSP00000150355.2, ENSMUST00000213643.2
      Conserved Domains (1) summary
      PTZ00184
      Location:172
      PTZ00184; calmodulin; Provisional
    4. XM_006511530.1XP_006511593.1  calmodulin-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SR54
      Related
      ENSMUSP00000149319.2, ENSMUST00000215968.2
      Conserved Domains (1) summary
      PTZ00184
      Location:1108
      PTZ00184; calmodulin; Provisional
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