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    Abhd14b abhydrolase domain containing 14b [ Mus musculus (house mouse) ]

    Gene ID: 76491, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Abhd14bprovided by MGI
    Official Full Name
    abhydrolase domain containing 14bprovided by MGI
    Primary source
    MGI:MGI:1923741
    See related
    Ensembl:ENSMUSG00000042073 AllianceGenome:MGI:1923741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810013B01Rik
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in epidermis; nose; and renal calyx. Orthologous to human ABHD14B (abhydrolase domain containing 14B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 174.5), liver adult (RPKM 134.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd14b in Genome Data Viewer
    Location:
    9 F1; 9 57.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106324936..106330122)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106447737..106452923)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene aminoacylase 1 Neighboring gene abhydrolase domain containing 14A Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E716

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals. Rajendran A, et al. J Biol Chem, 2022 Jul. PMID 35700823, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals.
      Title: A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative protein-lysine deacylase ABHD14B
    Names
    CCG1-interacting factor B
    abhydrolase domain-containing protein 14B
    alpha/beta hydrolase domain-containing protein 14B
    protein ABHD14B
    NP_083907.3
    XP_006511911.1
    XP_017169172.1
    XP_030100558.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029631.3 → NP_083907.3  putative protein-lysine deacylase ABHD14B

      See identical proteins and their annotated locations for NP_083907.3

      Status: VALIDATED

      Source sequence(s)
      AK007469, BF461776, CJ186593
      Consensus CDS
      CCDS23478.1
      UniProtKB/Swiss-Prot
      Q8VCR7
      UniProtKB/TrEMBL
      A0A087WQN8, E9QN99
      Related
      ENSMUSP00000038755.8, ENSMUST00000048527.15
      Conserved Domains (1) summary
      COG0596
      Location:10 → 209
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106324936..106330122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244698.1 → XP_030100558.1  putative protein-lysine deacylase ABHD14B isoform X1

      UniProtKB/Swiss-Prot
      Q8VCR7
      UniProtKB/TrEMBL
      A0A087WQN8, E9QN99
      Related
      ENSMUSP00000150885.2, ENSMUST00000216130.2
      Conserved Domains (1) summary
      COG0596
      Location:10 → 209
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    2. XM_017313683.3 → XP_017169172.1  putative protein-lysine deacylase ABHD14B isoform X1

      UniProtKB/Swiss-Prot
      Q8VCR7
      UniProtKB/TrEMBL
      A0A087WQN8, E9QN99
      Related
      ENSMUSP00000141151.2, ENSMUST00000186361.7
      Conserved Domains (1) summary
      COG0596
      Location:10 → 209
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    3. XM_006511848.5 → XP_006511911.1  putative protein-lysine deacylase ABHD14B isoform X1

      See identical proteins and their annotated locations for XP_006511911.1

      UniProtKB/Swiss-Prot
      Q8VCR7
      UniProtKB/TrEMBL
      A0A087WQN8, E9QN99
      Related
      ENSMUSP00000140279.3, ENSMUST00000185347.8
      Conserved Domains (1) summary
      COG0596
      Location:10 → 209
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCR7.1 GenPept UniProtKB/Swiss-Prot:Q8VCR7

    Gene LinkOut

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