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    TBX3 T-box transcription factor 3 [ Gallus gallus (chicken) ]

    Gene ID: 374202, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TBX3provided by CGNC
    Official Full Name
    T-box transcription factor 3provided by CGNC
    Primary source
    CGNC:49082
    See related
    Ensembl:ENSGALG00010000443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TBX3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (11922573..12225420)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (11934477..12237366)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106869 Neighboring gene uncharacterized LOC121106870 Neighboring gene uncharacterized LOC121106871 Neighboring gene uncharacterized LOC124417237 Neighboring gene uncharacterized LOC107054672 Neighboring gene T-box 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity. Logan M, et al. Development, 1998 Aug. PMID 9655805
    2. Tbx genes and limb identity in chick embryo development. Isaac A, et al. Development, 1998 May. PMID 9550719
    3. Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling. Suzuki T, et al. Dev Cell, 2004 Jan. PMID 14723846
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac chamber development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-box transcription factor TBX3
    Names
    T-Box protein 3
    T-box 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270878.2 → NP_001257807.1  T-box transcription factor TBX3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000260
      UniProtKB/TrEMBL
      A0A1D5NXF3
      Related
      ENSGALP00010000489.1, ENSGALT00010000925.1
      Conserved Domains (2) summary
      pfam12598
      Location:305 → 375
      TBX; T-box transcription factor
      cd20188
      Location:106 → 287
      T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      11922573..12225420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046901073.1 → XP_046757029.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    2. XM_040647960.2 → XP_040503894.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3
      Conserved Domains (2) summary
      pfam12598
      Location:305 → 375
      TBX; T-box transcription factor
      cd20188
      Location:106 → 287
      T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins

    3. XM_046901069.1 → XP_046757025.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    4. XM_046901066.1 → XP_046757022.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    5. XM_046901071.1 → XP_046757027.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    6. XM_046901064.1 → XP_046757020.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    7. XM_046901065.1 → XP_046757021.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    8. XM_046901070.1 → XP_046757026.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    9. XM_046901067.1 → XP_046757023.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    10. XM_046901072.1 → XP_046757028.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    11. XM_046901068.1 → XP_046757024.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    12. XM_046901074.1 → XP_046757030.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    13. XM_015294834.4 → XP_015150320.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3
      Conserved Domains (2) summary
      pfam12598
      Location:305 → 375
      TBX; T-box transcription factor
      cd20188
      Location:106 → 287
      T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins

    14. XM_040647961.2 → XP_040503895.1  T-box transcription factor TBX3 isoform X2

      Conserved Domains (1) summary
      smart00425
      Location:1 → 159
      TBOX; Domain first found in the mice T locus (Brachyury) protein

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      11934477..12237366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927985.1 → XP_046783941.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    2. XM_046927978.1 → XP_046783934.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    3. XM_046927982.1 → XP_046783938.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    4. XM_046927980.1 → XP_046783936.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    5. XM_046927984.1 → XP_046783940.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    6. XM_046927979.1 → XP_046783935.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    7. XM_046927983.1 → XP_046783939.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    8. XM_046927981.1 → XP_046783937.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    9. XM_046927986.1 → XP_046783942.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    10. XM_046927977.1 → XP_046783933.1  T-box transcription factor TBX3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5NXF3

    11. XM_046927987.1 → XP_046783943.1  T-box transcription factor TBX3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73718.1 GenPept UniProtKB/Swiss-Prot:O73718

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