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    Hba-a2 hemoglobin alpha, adult chain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360504, updated on 2-May-2024

    Summary

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    Official Symbol
    Hba-a2provided by RGD
    Official Full Name
    hemoglobin alpha, adult chain 2provided by RGD
    Primary source
    RGD:1359364
    See related
    AllianceGenome:RGD:1359364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hba1; Hba2; Glnc2; Glnc3; Hba-a1
    Summary
    Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to estradiol. Predicted to be located in extracellular space. Predicted to be part of cytosolic small ribosomal subunit; haptoglobin-hemoglobin complex; and hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 180728.0), Lung (RPKM 47136.6) and 1 other tissue See more
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    Genomic context

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    See Hba-a2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15828291..15829138, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15323830..15324677, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15589364..15590207, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hemoglobin alpha, adult chain 3 Neighboring gene hemoglobin subunit theta-1-like Neighboring gene hemoglobin subunit theta 1B Neighboring gene hemoglobin alpha, adult chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. Sárvári M, et al. Endocrinology, 2010 Aug. PMID 20534718
    2. Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion. Liebhaber SA, et al. J Clin Invest, 1985 Sep. PMID 4044827, Free PMC Article
    3. Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina. Deng L, et al. Hum Reprod, 2009 Jan. PMID 18786935
    4. Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Heimann AS, et al. Proc Natl Acad Sci U S A, 2007 Dec 18. PMID 18077343, Free PMC Article
    5. Initiation codon mutation as a cause of alpha thalassemia. Pirastu M, et al. J Biol Chem, 1984 Oct 25. PMID 6490612

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to haptoglobin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to haptoglobin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbon dioxide transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of haptoglobin-hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of haptoglobin-hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of hemoglobin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin alpha, adult chain 2
    Names
    2-alpha globin
    2-alpha-1 globin
    Alpha-1/2-globin
    Hemoglobin alpha-1/2 chain
    Hemoglobin subunit alpha-1/2
    globin c2
    globin c3
    hemoglobin alpha 2 chain
    hemoglobin, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007722.2 → NP_001007723.1  hemoglobin alpha, adult chain 2

      See identical proteins and their annotated locations for NP_001007723.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A1K0FUH3
      Conserved Domains (1) summary
      cd08927
      Location:3 → 142
      Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15828291..15829138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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