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    Pcyt2 phosphate cytidylyltransferase 2, ethanolamine [ Mus musculus (house mouse) ]

    Gene ID: 68671, updated on 5-Jan-2022

    Summary

    Official Symbol
    Pcyt2provided by MGI
    Official Full Name
    phosphate cytidylyltransferase 2, ethanolamineprovided by MGI
    Primary source
    MGI:MGI:1915921
    See related
    Ensembl:ENSMUSG00000025137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ET; 1110033E03Rik
    Summary
    Enables ethanolamine-phosphate cytidylyltransferase activity. Involved in phosphatidylethanolamine biosynthetic process. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in liver adult (RPKM 301.0), duodenum adult (RPKM 190.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pcyt2 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120500888..120508784, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120610062..120617947, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120471401..120479204, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B Neighboring gene sirtuin 7 Neighboring gene microRNA 6936 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) Neighboring gene predicted gene, 17586

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ethanolamine-phosphate cytidylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ethanolamine-phosphate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ethanolamine-phosphate cytidylyltransferase
    Names
    CTP:phosphoethanolamine cytidylyltransferase
    phosphorylethanolamine transferase
    NP_001334544.1
    NP_001349930.1
    NP_077191.2
    XP_006534132.1
    XP_006534134.1
    XP_036012825.1
    XP_036012826.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347615.2NP_001334544.1  ethanolamine-phosphate cytidylyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663030
      Consensus CDS
      CCDS83946.1
      UniProtKB/TrEMBL
      A2ABY3
      Related
      ENSMUSP00000101794.4, ENSMUST00000106188.4
    2. NM_001363001.1NP_001349930.1  ethanolamine-phosphate cytidylyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK144544, AL663030
      Conserved Domains (1) summary
      cl28626
      Location:15345
      PLN02406; ethanolamine-phosphate cytidylyltransferase
    3. NM_024229.3NP_077191.2  ethanolamine-phosphate cytidylyltransferase isoform 1

      See identical proteins and their annotated locations for NP_077191.2

      Status: VALIDATED

      Source sequence(s)
      AK140458, AL663030
      Consensus CDS
      CCDS25747.1
      UniProtKB/Swiss-Prot
      Q922E4
      UniProtKB/TrEMBL
      Q3USD5
      Related
      ENSMUSP00000026129.10, ENSMUST00000026129.16
      Conserved Domains (3) summary
      PTZ00308
      Location:15390
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02173
      Location:230382
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
      cd02174
      Location:21163
      CCT; CTP:phosphocholine cytidylyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120500888..120508784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156933.1XP_036012826.1  ethanolamine-phosphate cytidylyltransferase isoform X4

      Conserved Domains (1) summary
      PTZ00308
      Location:15318
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    2. XM_036156932.1XP_036012825.1  ethanolamine-phosphate cytidylyltransferase isoform X3

      Conserved Domains (1) summary
      PTZ00308
      Location:15336
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    3. XM_006534071.3XP_006534134.1  ethanolamine-phosphate cytidylyltransferase isoform X2

      Conserved Domains (1) summary
      PTZ00308
      Location:15371
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    4. XM_006534069.3XP_006534132.1  ethanolamine-phosphate cytidylyltransferase isoform X1

      Conserved Domains (1) summary
      PTZ00308
      Location:15389
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    RNA

    1. XR_001780048.2 RNA Sequence

    2. XR_004937013.1 RNA Sequence

    3. XR_003949495.2 RNA Sequence

    4. XR_879733.4 RNA Sequence

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