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    Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) [ Mus musculus (house mouse) ]

    Gene ID: 52858, updated on 25-Jan-2022

    Summary

    Official Symbol
    Cdiptprovided by MGI
    Official Full Name
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)provided by MGI
    Primary source
    MGI:MGI:105491
    See related
    Ensembl:ENSMUSG00000030682 AllianceGenome:MGI:105491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pis; Pis1; D7Bwg0575e; 9530042F15Rik
    Summary
    Predicted to enable several functions, including CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; diacylglycerol binding activity; and manganese ion binding activity. Predicted to be involved in CDP-diacylglycerol metabolic process and phosphatidylinositol biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in musculature; nervous system; and urinary system. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 67.2), duodenum adult (RPKM 64.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cdipt in Genome Data Viewer
    Location:
    7 F3; 7 69.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126575630..126579671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126976458..126980499)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134119863..134124015)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like 2 Neighboring gene CDIP transferase, opposite strand Neighboring gene major vault protein Neighboring gene PAXIP1 associated glutamate rich protein 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Names
    PI synthase
    phosphatidylinositol synthase
    ptdIns synthase
    NP_001334585.1
    NP_001366189.1
    NP_080914.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347656.2NP_001334585.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS85418.1
      UniProtKB/TrEMBL
      A0A0U1RPV3
      Related
      ENSMUSP00000146137.2, ENSMUST00000206346.2
    2. NM_001379260.1NP_001366189.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC122863
      Conserved Domains (1) summary
      pfam01066
      Location:1072
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    3. NM_026638.4NP_080914.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS21853.1
      UniProtKB/Swiss-Prot
      Q8VDP6
      Related
      ENSMUSP00000032920.4, ENSMUST00000032920.5
      Conserved Domains (1) summary
      pfam01066
      Location:1072
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126575630..126579671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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