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    Zmynd15 zinc finger, MYND-type containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 574428, updated on 14-May-2024

    Summary

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    Official Symbol
    Zmynd15provided by MGI
    Official Full Name
    zinc finger, MYND-type containing 15provided by MGI
    Primary source
    MGI:MGI:3603821
    See related
    Ensembl:ENSMUSG00000040829 AllianceGenome:MGI:3603821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables histone deacetylase binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated and spermatid development. Located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in spermatogenic failure 14. Orthologous to human ZMYND15 (zinc finger MYND-type containing 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 57.0), thymus adult (RPKM 8.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70350259..70357028)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70459433..70466204)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene arrestin, beta 2 Neighboring gene microRNA 7115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70265674-70265783 Neighboring gene mediator complex subunit 11 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene transmembrane 4 superfamily member 5 Neighboring gene vitelline membrane outer layer 1 homolog (chicken)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Aslanian AM, et al. Circulation, 2006 Aug 8. PMID 16880330
    2. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. Yan W, et al. J Biol Chem, 2010 Oct 8. PMID 20675388, Free PMC Article
    3. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. Saita S, et al. J Biol Chem, 2014 Sep 12. PMID 25077969, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility.
      Title: Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYND domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029929.3 → NP_001025100.1  zinc finger MYND domain-containing protein 15 isoform 1

      See identical proteins and their annotated locations for NP_001025100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029988, AL596096, BY206104
      Consensus CDS
      CCDS24949.1
      UniProtKB/Swiss-Prot
      Q3TAD1, Q8C0R7
      UniProtKB/TrEMBL
      A2A642, A2CFF1
      Related
      ENSMUSP00000048816.4, ENSMUST00000039093.10
      Conserved Domains (1) summary
      pfam01753
      Location:307 → 353
      zf-MYND; MYND finger

    2. NM_001348337.1 → NP_001335266.1  zinc finger MYND domain-containing protein 15 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK029988, AL596096, BY206104
      Consensus CDS
      CCDS88182.1
      UniProtKB/TrEMBL
      A2A642
      Related
      ENSMUSP00000104203.3, ENSMUST00000108563.9
      Conserved Domains (1) summary
      pfam01753
      Location:177 → 223
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70350259..70357028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533835.3 → XP_006533898.1  zinc finger MYND domain-containing protein 15 isoform X7

      See identical proteins and their annotated locations for XP_006533898.1

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:90 → 136
      zf-MYND; MYND finger

    2. XM_006533834.3 → XP_006533897.1  zinc finger MYND domain-containing protein 15 isoform X7

      See identical proteins and their annotated locations for XP_006533897.1

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:90 → 136
      zf-MYND; MYND finger

    3. XM_006533833.5 → XP_006533896.1  zinc finger MYND domain-containing protein 15 isoform X6

      See identical proteins and their annotated locations for XP_006533896.1

      UniProtKB/TrEMBL
      A2A642
      Related
      ENSMUST00000136029.2
      Conserved Domains (1) summary
      pfam01753
      Location:131 → 177
      zf-MYND; MYND finger

    4. XM_006533836.4 → XP_006533899.1  zinc finger MYND domain-containing protein 15 isoform X8

      See identical proteins and their annotated locations for XP_006533899.1

      UniProtKB/TrEMBL
      Q6ZQM1
      Conserved Domains (1) summary
      pfam01753
      Location:131 → 177
      zf-MYND; MYND finger

    5. XM_006533830.5 → XP_006533893.1  zinc finger MYND domain-containing protein 15 isoform X2

      See identical proteins and their annotated locations for XP_006533893.1

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:307 → 353
      zf-MYND; MYND finger

    6. XM_036156869.1 → XP_036012762.1  zinc finger MYND domain-containing protein 15 isoform X3

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:307 → 353
      zf-MYND; MYND finger

    7. XM_036156868.1 → XP_036012761.1  zinc finger MYND domain-containing protein 15 isoform X1

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:306 → 352
      zf-MYND; MYND finger

    8. XM_006533832.5 → XP_006533895.1  zinc finger MYND domain-containing protein 15 isoform X4

      See identical proteins and their annotated locations for XP_006533895.1

      UniProtKB/TrEMBL
      A2A642, Q5F2D4
      Related
      ENSMUSP00000090635.4, ENSMUST00000092958.4
      Conserved Domains (1) summary
      pfam01753
      Location:306 → 352
      zf-MYND; MYND finger

    9. XM_011249160.4 → XP_011247462.1  zinc finger MYND domain-containing protein 15 isoform X5

      See identical proteins and their annotated locations for XP_011247462.1

      UniProtKB/TrEMBL
      A2A642
      Conserved Domains (1) summary
      pfam01753
      Location:132 → 178
      zf-MYND; MYND finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0R7.1 GenPept UniProtKB/Swiss-Prot:Q8C0R7

    Gene LinkOut

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