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    mt:ND1 mitochondrial NADH-ubiquinone oxidoreductase chain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 19893558, updated on 26-Apr-2024

    Summary

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    Official Symbol
    mt:ND1provided by FlyBase
    Official Full Name
    mitochondrial NADH-ubiquinone oxidoreductase chain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0013679
    Locus tag
    Dmel_CG34092
    See related
    AllianceGenome:FB:FBgn0013679
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    mt:ND1; ND1
    Summary
    Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in aerobic respiration. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mt:ND1 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) MT (non-nuclear) NC_024511.2 (11721..12659, complement)

    Chromosome MT - NC_024511.2Genomic Context describing neighboring genes Neighboring gene mitochondrial Cytochrome b Neighboring gene mitochondrial transfer RNA:Serine-TGA Neighboring gene mitochondrial transfer RNA:Leucine-TAG Neighboring gene mitochondrial large ribosomal RNA Neighboring gene mitochondrial transfer RNA:Valine-TAC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_024511.2 Chromosome MT Reference Release 6 plus ISO1 MT non-nuclear

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Leber hereditary optic neuropathy due to a new ND1 mutation. Soldath P, et al. Ophthalmic Genet, 2017 Sep-Oct. PMID 28139165
    2. Presence of mitochondrial large ribosomal RNA outside mitochondria in germ plasm of Drosophila melanogaster. Kobayashi S, et al. Science, 1993 Jun 4. PMID 7684857
    3. Effects of overexpression of mitochondrial transcription factor A on lifespan and oxidative stress response in Drosophila melanogaster. Matsuda T, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23206694
    4. Towards understanding the evolutionary dynamics of mtDNA. Towarnicki SG, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2020 Dec. PMID 33026269
    5. Complete mitochondrial genome sequences of thirteen globally sourced strains of fruit fly (Drosophila melanogaster) form a powerful model for mitochondrial research. Wolff JN, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2016 Nov. PMID 26709744

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase subunit 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_024511.2 Reference assembly

      Range
      11721..12659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009047278.1 Peptide Sequence

      See identical proteins and their annotated locations for YP_009047278.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P18929
      UniProtKB/TrEMBL
      A0A343ASV4, J7FM77, Q9MGN3, Q9MGN8
      Related
      FBpp0390631
      Conserved Domains (1) summary
      MTH00193
      Location:16 → 308
      ND1; NADH dehydrogenase subunit 1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18929.3 P18929
    Q9MGN3 Q9MGN3
    Q9MGN8 Q9MGN8
    Q9MJC6 Q9MJC6
    V9H007 V9H007

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