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    FGF1 fibroblast growth factor 1 [ Homo sapiens (human) ]

    Gene ID: 2246, updated on 11-Apr-2024

    Summary

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    Official Symbol
    FGF1provided by HGNC
    Official Full Name
    fibroblast growth factor 1provided by HGNC
    Primary source
    HGNC:HGNC:3665
    See related
    Ensembl:ENSG00000113578 MIM:131220; AllianceGenome:HGNC:3665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
    Expression
    Biased expression in brain (RPKM 36.0), kidney (RPKM 21.0) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (142592178..142698070, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143123428..143229306, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141971743..142077635, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141711019-141711518 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:141721844-141723043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141734625-141735426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141735427-141736228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16471 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:141740409-141740647 Neighboring gene Sharpr-MPRA regulatory region 738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141743173-141743894 Neighboring gene SPRY4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141768171-141768672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141771555-141772234 Neighboring gene Sharpr-MPRA regulatory region 12170 Neighboring gene Sharpr-MPRA regulatory region 9292 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141854065-141854633 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:141854634-141855201 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141855756-141856266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141902675-141903176 Neighboring gene VISTA enhancer hs1640 Neighboring gene ribosomal protein S12 pseudogene 10 Neighboring gene FGF1 promoter D Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:142024170-142025369 Neighboring gene FGF1 promoter C Neighboring gene Sharpr-MPRA regulatory region 3450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142039508-142040008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142040009-142040509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047003-142047511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047512-142048019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142049247-142049746 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142052360-142052880 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:142064129-142064998 Neighboring gene FGF1 promoter B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142150581-142151416 Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142176991-142177492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16477 Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. Lampart A, et al. Cells, 2022 Feb 2. PMID 35159330, Free PMC Article
    2. FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei. Gao Y, et al. Cell Biochem Biophys, 2022 Jun. PMID 34796419
    3. Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding. Govind Kumar V, et al. J Phys Chem B, 2021 Nov 25. PMID 34762427
    4. Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor. Agrawal S, et al. Sci Rep, 2021 Aug 2. PMID 34341408, Free PMC Article
    5. Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis. Habibi H, et al. J Orthop Sci, 2022 Mar. PMID 33637374

    See all (257) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells.
      Title: The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells.
    2. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53.
      Title: Intracellular FGF1 protects cells from apoptosis through direct interaction with p53.
    3. FGF1 reduces cartilage injury in osteoarthritis via regulating AMPK/Nrf2 pathway.
      Title: FGF1 reduces cartilage injury in osteoarthritis via regulating AMPK/Nrf2 pathway.
    4. MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells Through FGF1.
      Title: MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells Through FGF1.
    5. FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei.
      Title: FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei.
    6. Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells.
      Title: Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells.
    7. Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis.
      Title: Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis.
    8. Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding.
      Title: Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding.
    9. Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos.
      Title: Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos.
    10. Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor.
      Title: Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor.
    Submit: New GeneRIF Correction See all GeneRIFs (148)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neurotoxic effects are inhibited by the presence of fibroblast growth factor 1 (FGF1) PubMed
    Tat tat HIV-1 Tat induces the expression and secretion of FGF-1 from primary murine embryonic fibroblasts, an effect that may be relevant to the pathophysiological development of AIDS associated Kaposi's sarcoma PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S100 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fibroblast growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in branch elongation involved in ureteric bud branching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mesonephric epithelium development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organ induction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cholesterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endothelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 1
    Names
    beta-endothelial cell growth factor
    endothelial cell growth factor, alpha
    endothelial cell growth factor, beta
    fibroblast growth factor 1 (acidic)
    heparin-binding growth factor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000800.5 → NP_000791.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000791.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the full-length isoform (1). Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DA189432
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000338548.2, ENST00000337706.7
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    2. NM_001144892.3 → NP_001138364.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001138364.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, BC032697
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000352329.6, ENST00000359370.10
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    3. NM_001144934.2 → NP_001138406.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001138406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DA649213
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000404742.2, ENST00000441680.6
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    4. NM_001144935.2 → NP_001138407.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001138407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DA389088, DC344309
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000396195.2, ENST00000419524.6
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    5. NM_001257205.1 → NP_001244134.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001244134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DC344309, DQ655917
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000480791.1, ENST00000621536.4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    6. NM_001257206.2 → NP_001244135.1  fibroblast growth factor 1 isoform 4

      See identical proteins and their annotated locations for NP_001244135.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AC005370, AI283639, AK289762, DC344309
      UniProtKB/TrEMBL
      A8K147
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    7. NM_001257207.2 → NP_001244136.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001244136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, AK312301
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000479024.1, ENST00000612258.4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    8. NM_001257208.2 → NP_001244137.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001244137.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DB220987
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000367285.1, ENST00000378046.5
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    9. NM_001257209.1 → NP_001244138.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001244138.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DA111414, DB220987
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000480980.1, ENST00000619447.4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    10. NM_001257210.2 → NP_001244139.1  fibroblast growth factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001244139.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
      Source sequence(s)
      AC005370, AI283639, DA660034
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Related
      ENSP00000481868.1, ENST00000610990.4
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    11. NM_001257211.2 → NP_001244140.1  fibroblast growth factor 1 isoform 4

      See identical proteins and their annotated locations for NP_001244140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AC005370, AI283639, DA388578, DB220987
      UniProtKB/TrEMBL
      A8K147
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    12. NM_001257212.2 → NP_001244141.1  fibroblast growth factor 1 isoform 4

      See identical proteins and their annotated locations for NP_001244141.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AC005370, AI283639, DA575048
      UniProtKB/TrEMBL
      A8K147
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    13. NM_001354951.2 → NP_001341880.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1, 4-7, 9-12, and 16-20, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    14. NM_001354952.2 → NP_001341881.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1, 4-7, 9-12, 15, and 17-20, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    15. NM_001354953.2 → NP_001341882.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1, 4-7, 9-12, 15, 16 and 18-20, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    16. NM_001354954.2 → NP_001341883.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 1, 4-7, 9-12, 15-17, 19, and 20, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    17. NM_001354955.2 → NP_001341884.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 1, 4-7, 9-12, 15-18, and 20, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    18. NM_001354956.2 → NP_001341885.1  fibroblast growth factor 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 1, 4-7, 9-12, and 15-19, encodes isoform 1.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4275.1
      UniProtKB/Swiss-Prot
      B2R5T0, D3DQF2, P05230, P07502, Q16588
      UniProtKB/TrEMBL
      A0A7U3JVZ2
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 148
      FGF; Fibroblast growth factor

    19. NM_001354957.2 → NP_001341886.1  fibroblast growth factor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 8, 13, 14, and 22, encodes isoform 4.
      Source sequence(s)
      AC005370, AC005592
      UniProtKB/TrEMBL
      A8K147
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    20. NM_001354958.2 → NP_001341887.1  fibroblast growth factor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 8, 13, 14, and 21, encodes isoform 4.
      Source sequence(s)
      AC005370, AC005592
      UniProtKB/TrEMBL
      A8K147
      Conserved Domains (1) summary
      pfam00167
      Location:25 → 147
      FGF; Fibroblast growth factor

    21. NM_001354959.2 → NP_001341888.1  fibroblast growth factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 2 and 24-27, encodes isoform 2.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    22. NM_001354961.2 → NP_001341890.1  fibroblast growth factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 2, 23, and 25-27, encodes isoform 2.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    23. NM_001354962.2 → NP_001341891.1  fibroblast growth factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 2, 23, 24, 26, and 27, encodes isoform 2.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    24. NM_001354963.2 → NP_001341892.1  fibroblast growth factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 2, 23-25, and 27, encodes isoform 2.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    25. NM_001354964.2 → NP_001341893.1  fibroblast growth factor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 2 and 23-26, encodes isoform 2.
      Source sequence(s)
      AC005370, AC005592
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    26. NM_033136.4 → NP_149127.1  fibroblast growth factor 1 isoform 2

      See identical proteins and their annotated locations for NP_149127.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 23-27 encode the same isoform (2).
      Source sequence(s)
      AC005370, AI283639, DA326831
      Consensus CDS
      CCDS4276.1
      UniProtKB/TrEMBL
      C9JDC5
      Related
      ENSP00000354231.5, ENST00000360966.9
      Conserved Domains (1) summary
      cl00060
      Location:25 → 57
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    27. NM_033137.4 → NP_149128.1  fibroblast growth factor 1 isoform 3

      See identical proteins and their annotated locations for NP_149128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks a coding exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC005370, AC005592
      UniProtKB/TrEMBL
      C9JDC5, Q16089
      Conserved Domains (1) summary
      cl00060
      Location:25 → 56
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      142592178..142698070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      143123428..143229306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05230.1 GenPept UniProtKB/Swiss-Prot:P05230

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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