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    Itpka inositol-trisphosphate 3-kinase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81677, updated on 30-Sep-2021

    Summary

    Official Symbol
    Itpkaprovided by RGD
    Official Full Name
    inositol-trisphosphate 3-kinase Aprovided by RGD
    Primary source
    RGD:619950
    See related
    EnsemblRapid:ENSRNOG00000005284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    an enzyme that catalyses the phosphorylation of InsP3 to inositol 1,3,4,5-tetrakisphosphate (InsP4) [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 127.2), Testes (RPKM 126.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Itpka in Genome Data Viewer
    Location:
    3q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106726036..106734601)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111545007..111553605)

    Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene RNA polymerase II associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase A
    Names
    IP3 3-kinase A
    IP3K A
    inositol 1,4,5-triphosphate 3-kinase
    inositol 1,4,5-trisphosphate 3-kinase A
    inositol 145-triphosphate 3-kinase
    insP 3-kinase A
    NP_112307.2
    XP_038961845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031045.2NP_112307.2  inositol-trisphosphate 3-kinase A

      See identical proteins and their annotated locations for NP_112307.2

      Status: VALIDATED

      Source sequence(s)
      BQ204027, JACYVU010000118, M29787
      UniProtKB/Swiss-Prot
      P17105
      Related
      ENSRNOP00000007247.1, ENSRNOT00000007247.4
      Conserved Domains (1) summary
      pfam03770
      Location:243453
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

      Range
      106726036..106734601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105917.1XP_038961845.1  inositol-trisphosphate 3-kinase A isoform X1

      Conserved Domains (1) summary
      pfam03770
      Location:116326
      IPK; Inositol polyphosphate kinase
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