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    Maged2 MAGE family member D2 [ Mus musculus (house mouse) ]

    Gene ID: 80884, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Maged2provided by MGI
    Official Full Name
    MAGE family member D2provided by MGI
    Primary source
    MGI:MGI:1933391
    See related
    Ensembl:ENSMUSG00000025268 AllianceGenome:MGI:1933391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF1; Mage-d2; 4833439A22Rik
    Summary
    Predicted to be involved in female pregnancy; negative regulation of transcription by RNA polymerase II; and renal sodium ion absorption. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; egg cylinder; genitourinary system; and liver. Human ortholog(s) of this gene implicated in Bartter disease type 5. Orthologous to human MAGED2 (MAGE family member D2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 115.6), placenta adult (RPKM 69.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F3; X 68.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149589417..149597358, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150806421..150814362, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33991 Neighboring gene STARR-seq mESC enhancer starr_48071 Neighboring gene STARR-seq mESC enhancer starr_48072 Neighboring gene predicted gene, 18773 Neighboring gene predicted gene, 24907 Neighboring gene predicted gene, 54086 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells. Valiño-Rivas L, et al. Nephrol Dial Transplant, 2019 Sep 1. PMID 30541139
    2. Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades. De Donato M, et al. Mamm Genome, 2017 Oct. PMID 28516231
    3. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese K, et al. Cytogenet Cell Genet, 2001. PMID 11856887
    4. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. Bertrand M, et al. Dev Dyn, 2004 Jun. PMID 15162511
    5. Mammalian small nucleolar RNAs are mobile genetic elements. Weber MJ. PLoS Genet, 2006 Dec 8. PMID 17154719, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High MAGED2 expression is associated with tubular cell injury during kidney disease.
      Title: MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.
    2. Maged2 is mainly expressed in tissues of mesodermal origin
      Title: Comparative expression analysis of the MAGED genes during embryogenesis and brain development.
    3. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues
      Title: Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal sodium ion absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen D2
    Names
    melanoma antigen, family D, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199246.2 → NP_001186175.1  melanoma-associated antigen D2

      See identical proteins and their annotated locations for NP_001186175.1

      Status: VALIDATED

      Source sequence(s)
      BB869272, BC058581
      Consensus CDS
      CCDS30466.1
      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Related
      ENSMUSP00000108320.2, ENSMUST00000112700.8
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    2. NM_001358566.1 → NP_001345495.1  melanoma-associated antigen D2

      Status: VALIDATED

      Source sequence(s)
      AL672282
      Consensus CDS
      CCDS30466.1
      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    3. NM_001358567.1 → NP_001345496.1  melanoma-associated antigen D2

      Status: VALIDATED

      Source sequence(s)
      AL672282
      Consensus CDS
      CCDS30466.1
      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    4. NM_001358568.1 → NP_001345497.1  melanoma-associated antigen D2

      Status: VALIDATED

      Source sequence(s)
      AL672282
      Consensus CDS
      CCDS30466.1
      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Related
      ENSMUSP00000108317.4, ENSMUST00000112697.10
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    5. NM_030700.3 → NP_109625.1  melanoma-associated antigen D2

      See identical proteins and their annotated locations for NP_109625.1

      Status: VALIDATED

      Source sequence(s)
      AJ277114, BP757994, CA752082
      Consensus CDS
      CCDS30466.1
      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Related
      ENSMUSP00000108319.3, ENSMUST00000112699.9
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149589417..149597358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247882.2 → XP_011246184.1  melanoma-associated antigen D2 isoform X2

      See identical proteins and their annotated locations for XP_011246184.1

      UniProtKB/TrEMBL
      Q3TFU3, Q99PB4
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family

    2. XM_006528998.5 → XP_006529061.1  melanoma-associated antigen D2 isoform X1

      See identical proteins and their annotated locations for XP_006529061.1

      UniProtKB/TrEMBL
      Q3TFU3, Q9ER67
      Conserved Domains (3) summary
      PRK13335
      Location:32 → 125
      PRK13335; superantigen-like protein SSL3; Reviewed
      PRK13914
      Location:33 → 224
      PRK13914; invasion associated endopeptidase
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
    Nucleotide Protein Strain
    Heading Accession and Version

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