U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    nanS N-acetyl-9-O-acetylneuraminate esterase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948835, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    nanS
    Gene description
    N-acetyl-9-O-acetylneuraminate esterase
    Primary source
    ASAP:ABE-0014130
    Locus tag
    b4309
    See related
    ECOCYC:G7919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4300; yjhS
    Summary
    yjhS is essential for growth on glycerol minimal medium . [More information is available at EcoCyc: G7919].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4536614..4537594, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene protein YthB Neighboring gene N-acetylneuraminate mutarotase Neighboring gene N-acetylneuraminate outer membrane channel

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. De-O-Acetylation of mucin-derived sialic acids by recombinant NanS-p esterases of Escherichia coli O157:H7 strain EDL933. Feuerbaum S, et al. Int J Med Microbiol, 2018 Dec. PMID 30340996, Free PMC Article
    2. Unexpected Diversity of Escherichia coli Sialate O-Acetyl Esterase NanS. Rangel A, et al. J Bacteriol, 2016 Oct 15. PMID 27481927, Free PMC Article
    3. YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid. Steenbergen SM, et al. J Bacteriol, 2009 Nov. PMID 19749043, Free PMC Article
    4. Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT. Severi E, et al. J Biol Chem, 2008 Feb 22. PMID 18063573
    5. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Joyce AR, et al. J Bacteriol, 2006 Dec. PMID 17012394, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An expression of sialic acid O-acetylesterases, NanS and NanS-p with a broad specificity could be an advantage in competition with the gut microbiota for nutrients and facilitate EHEC colonization in the human large intestine.
      Title: De-O-Acetylation of mucin-derived sialic acids by recombinant NanS-p esterases of Escherichia coli O157:H7 strain EDL933.
    2. The catabolism of the diacetylated form of host sialic acid requires a specialized esterase, NanS.
      Title: Unexpected Diversity of Escherichia coli Sialate O-Acetyl Esterase NanS.
    3. Data show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.
      Title: YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialate O-acetylesterase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables sialate O-acetylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sialate O-acetylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-acetylneuraminate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carboxylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    N-acetyl-9-O-acetylneuraminate esterase
    NP_418729.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4536614..4537594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418729.1 N-acetyl-9-O-acetylneuraminate esterase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418729.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AP61
      Conserved Domains (1) summary
      pfam03629
      Location:11 → 209
      SASA; Carbohydrate esterase, sialic acid-specific acetylesterase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.