Cd19 CD19 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd19provided by MGI
Official Full Name: CD19 antigenprovided by MGI
Primary source: MGI:MGI:88319
See related: Ensembl:ENSMUSG00000030724 AllianceGenome:MGI:88319
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 117.1), mammary gland adult (RPKM 26.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.01 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126007620..126016401, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126408448..126415148, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
Title: Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24.
Title: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24.
CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.
Title: CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.
Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19.
Title: Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19.
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.
Title: SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
Title: CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage.
Title: CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.
This study demonstrates that antiviral protective antibody-secreting cells (ASC) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent.
Title: Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.
this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
Title: Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.
autoimmunity induced by excessive BAFF production requires B1b B cells and CD19 signaling.
Title: BAFF-driven autoimmunity requires CD19 expression.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M62553 (e-PCR)
- UniSTS:124967

PMC123054P1 (e-PCR)
- UniSTS:270430

Cd19 (e-PCR), detects polymorphism
- UniSTS:265568

AW495831 (e-PCR)
- UniSTS:179653

Cd19 (e-PCR), detects polymorphism
- UniSTS:141271

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in B cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell proliferation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B-1 B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in antigen receptor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: B-lymphocyte antigen CD19

Names: differentiation antigen CD19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357091.2 → NP_001344020.1 B-lymphocyte antigen CD19 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC125322

Consensus CDS

CCDS90327.1

UniProtKB/TrEMBL

A0A0X1KG58, Q3U1A5

Related

ENSMUSP00000032968.7, ENSMUST00000032968.7

Conserved Domains (2) summary

smart00410
Location:183 → 263

IG_like; Immunoglobulin like

cd04979
Location:21 → 118

Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
NM_009844.3 → NP_033974.2 B-lymphocyte antigen CD19 isoform 1 precursor

See identical proteins and their annotated locations for NP_033974.2

Status: VALIDATED

Source sequence(s)

AC125322

Consensus CDS

CCDS21828.1

UniProtKB/Swiss-Prot

P25918, Q542B2

UniProtKB/TrEMBL

Q3TA95

Related

ENSMUSP00000145803.2, ENSMUST00000206325.2

Conserved Domains (3) summary

cd04979
Location:21 → 118

Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin

smart00410
Location:26 → 115

IG_like; Immunoglobulin like

cl11960
Location:180 → 259

Ig; Immunoglobulin domain

RNA

NR_178083.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC125322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

126007620..126016401 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152614.1 → XP_036008507.1 B-lymphocyte antigen CD19 isoform X1

UniProtKB/TrEMBL

Q3TQG5

Conserved Domains (2) summary

cd00096
Location:70 → 78

Ig; Ig strand B [structural motif]

cl11960
Location:65 → 147

Ig; Immunoglobulin domain
XM_036152615.1 → XP_036008508.1 B-lymphocyte antigen CD19 isoform X2

Related

ENSMUST00000205997.2