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    Ppp1r35 protein phosphatase 1, regulatory subunit 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684993, updated on 5-Mar-2024

    Summary

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    Symbol
    Ppp1r35provided by RGD
    Full Name
    protein phosphatase 1, regulatory subunit 35provided by RGD
    Primary source
    RGD:1584367
    See related
    AllianceGenome:RGD:1584367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatase binding activity. Predicted to be involved in negative regulation of phosphatase activity. Orthologous to human PPP1R35 (protein phosphatase 1 regulatory subunit 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 85.1), Thymus (RPKM 72.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24552709..24556040, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18915909..18919253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (21727485..21728678, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene paired immunoglobin like type 2 receptor beta 2 like 7 Neighboring gene paired immunoglobulin-like type 2 receptor alpha-like Neighboring gene zinc finger CW-type and PWWP domain containing 1 Neighboring gene methylphosphate capping enzyme Neighboring gene uncharacterized LOC134481171 Neighboring gene sperm acrosome developmental regulator Neighboring gene TSC22 domain family, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in notochord morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 35
    Names
    protein phosphatase 1 regulatory subunit 35-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109451.1 → NP_001102921.1  protein phosphatase 1 regulatory subunit 35

      See identical proteins and their annotated locations for NP_001102921.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6IZZ9
      Conserved Domains (1) summary
      pfam15503
      Location:107 → 253
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24552709..24556040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089744.1 → XP_038945672.1  protein phosphatase 1 regulatory subunit 35 isoform X3

      Conserved Domains (1) summary
      pfam15503
      Location:107 → 158
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

    2. XM_039089742.2 → XP_038945670.1  protein phosphatase 1 regulatory subunit 35 isoform X1

      UniProtKB/TrEMBL
      A6IZZ9
      Conserved Domains (1) summary
      pfam15503
      Location:107 → 253
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus

    3. XM_039089743.1 → XP_038945671.1  protein phosphatase 1 regulatory subunit 35 isoform X2

      Conserved Domains (1) summary
      pfam15503
      Location:107 → 158
      PPP1R35_C; Protein phosphatase 1 regulatory subunit 35 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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