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    APC1 Mitochondrial substrate carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836303, updated on 11-Apr-2024

    Summary

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    Gene symbol
    APC1
    Gene description
    Mitochondrial substrate carrier family protein
    Primary source
    Araport:AT5G61810
    Locus tag
    AT5G61810
    See related
    TAIR:AT5G61810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP/phosphate carrier 1; MAC9.1; MAC9_1
    Summary
    Encodes a mitochondrial ATP-Mg/Pi transporter. Binds to calcium.
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    Genomic context

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    See APC1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (24831574..24833984, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TUDOR-SN protein 2 Neighboring gene calnexin 1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene stress up-regulated Nod 19 protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro analyses of mitochondrial ATP/phosphate carriers from Arabidopsis thaliana revealed unexpected Ca(2+)-effects. Lorenz A, et al. BMC Plant Biol, 2015 Oct 6. PMID 26444389, Free PMC Article
    2. Functional characterization and organ distribution of three mitochondrial ATP-Mg/Pi carriers in Arabidopsis thaliana. Monné M, et al. Biochim Biophys Acta, 2015 Oct. PMID 26140942
    3. Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATP. Monné M, et al. J Bioenerg Biomembr, 2017 Oct. PMID 28695448
    4. Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import. Stael S, et al. FEBS Lett, 2011 Dec 15. PMID 22062157
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001037044.2
    NM_125575.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ADP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ADP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within AMP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ATP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ATP transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ATP transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial substrate carrier family protein
    NP_001032121.1
    • Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding, calcium ion binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G07320.1); Has 27340 Blast hits to 13937 proteins in 456 species: Archae - 0; Bacteria - 2; Metazoa - 11225; Fungi - 8377; Plants - 4746; Viruses - 5; Other Eukaryotes - 2985 (source: NCBI BLink).
    NP_568940.1
    • Mitochondrial substrate carrier family protein; FUNCTIONS IN: binding, calcium ion binding; INVOLVED IN: transport, transmembrane transport; LOCATED IN: mitochondrial inner membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Mitochondrial substrate carrier (InterPro:IPR001993), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), Mitochondrial carrier protein (InterPro:IPR002067), EF-HAND 2 (InterPro:IPR018249), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: Mitochondrial substrate carrier family protein (TAIR:AT5G07320.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24831574..24833984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125575.4 → NP_568940.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568940.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLS8
      UniProtKB/TrEMBL
      A0A178UGX9, A0A5S9YGU7
      Conserved Domains (2) summary
      COG5126
      Location:32 → 168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:209 → 475
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    2. NM_001037044.2 → NP_001032121.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K509
      Conserved Domains (3) summary
      smart00054
      Location:1 → 21
      EFh; EF-hand, calcium binding motif
      PTZ00169
      Location:66 → 332
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:148 → 236
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLS8.1

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