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    Dbp D site albumin promoter binding protein [ Mus musculus (house mouse) ]

    Gene ID: 13170, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dbpprovided by MGI
    Official Full Name
    D site albumin promoter binding proteinprovided by MGI
    Primary source
    MGI:MGI:94866
    See related
    Ensembl:ENSMUSG00000059824 AllianceGenome:MGI:94866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in adrenal adult (RPKM 215.0), bladder adult (RPKM 83.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45354658..45359579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45705100..45710203)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene sphingosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. Kwon PK, et al. Mol Cell Biol, 2019 Aug 15. PMID 31160492, Free PMC Article
    2. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger JA, et al. Genes Dev, 2000 Mar 15. PMID 10733528, Free PMC Article
    3. The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. Franken P, et al. J Neurosci, 2000 Jan 15. PMID 10632591, Free PMC Article
    4. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. Lopez-Molina L, et al. EMBO J, 1997 Nov 17. PMID 9362490, Free PMC Article
    5. Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory. Tam SKE, et al. Proc Natl Acad Sci U S A, 2021 Sep 28. PMID 34556572, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
      Title: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
    2. The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
      Title: The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
    3. Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.
      Title: Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice.
    4. D-box-mediated transcriptional regulation plays pivotal roles in input and output in the circadian clock system.
      Title: Functional D-box sequences reset the circadian clock and drive mRNA rhythms.
    5. Study proposes that the poly(C) cis-acting element within the Dbp proximal promoter region supports the Dbp mRNA oscillation amplitude and sustains the mRNA oscillation level of Dbp-controlled clock genes.
      Title: The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.
    6. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK.
      Title: PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.
    7. constitutive Dbp expression plays an important role in mediating hepatic dysfunction under chronic kidney disease. DBP was significantly decreased in 5/6Nx model mice.
      Title: Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
    8. Dbp plays a well-established role in circadian rhythms.
      Title: Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation.
    9. Expressions of Dbp and Arnt were dampened in the islets of a diabetic model mouse.
      Title: Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells.
    10. BMAL1 and CLOCK may act as Kamikaze activators, in that they are rapidly degraded once bound to Dbp chromatin.
      Title: Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    D site-binding protein
    Names
    albumin D box-binding protein
    albumin D-element-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412312.1 → NP_001399241.1  D site-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167242
      UniProtKB/TrEMBL
      A0A1B0GS46
      Related
      ENSMUSP00000147790.2, ENSMUST00000211513.2

    2. NM_001412313.1 → NP_001399242.1  D site-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC167242
      UniProtKB/TrEMBL
      Q5XFZ5

    3. NM_016974.4 → NP_058670.2  D site-binding protein isoform 1

      See identical proteins and their annotated locations for NP_058670.2

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS21260.1
      UniProtKB/Swiss-Prot
      Q60925, Q8VCX3
      UniProtKB/TrEMBL
      Q3USN7
      Related
      ENSMUSP00000079693.4, ENSMUST00000080885.12
      Conserved Domains (1) summary
      cd14695
      Location:254 → 313
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45354658..45359579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540597.2 → XP_006540660.1  D site-binding protein isoform X2

      Conserved Domains (1) summary
      cd14695
      Location:117 → 176
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60925.2 GenPept UniProtKB/Swiss-Prot:Q60925

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