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    cnx-1 Calnexin [ Caenorhabditis elegans ]

    Gene ID: 176390, updated on 25-Jan-2024

    Summary

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    Gene symbol
    cnx-1
    Gene description
    Calnexin
    Primary source
    WormBase:WBGene00000567
    Locus tag
    CELE_ZK632.6
    See related
    AllianceGenome:WB:WBGene00000567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium ion binding activity. Involved in IRE1-mediated unfolded protein response and response to heat. Located in perinuclear region of cytoplasm. Is expressed in copulatory spicule; excretory cell; nervous system; seam cell; and spermatheca. Orthologous to several human genes including CANX (calnexin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (9814364..9817137, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Gamma-Tubulin Associating Protein Neighboring gene DNA/RNA-binding protein Alba-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PAN2-PAN3 deadenylation complex subunit PAN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K(+) channels. Bai X, et al. J Gen Physiol, 2018 Aug 6. PMID 29941431, Free PMC Article
    2. Caenorhabditis elegans calnexin is N-glycosylated and required for stress response. Lee W, et al. Biochem Biophys Res Commun, 2005 Dec 16. PMID 16256074
    3. CLHM-1 is a functionally conserved and conditionally toxic Ca2+-permeable ion channel in Caenorhabditis elegans. Tanis JE, et al. J Neurosci, 2013 Jul 24. PMID 23884934, Free PMC Article
    4. Calnexin revealed as an ether-a-go-go chaperone by getting mutant worms up and going. Pierce JT. J Gen Physiol, 2018 Aug 6. PMID 29970410, Free PMC Article
    5. The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3. He L, et al. Dis Model Mech, 2012 Nov. PMID 22569626, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IRE1-mediated unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calnexin
    NP_001293601.1
    • Confirmed by transcript evidence
    NP_499176.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9814364..9817137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066775.7 → NP_499176.1  Calnexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34652
      Conserved Domains (1) summary
      pfam00262
      Location:61 → 432
      Calreticulin; Calreticulin family

    2. NM_001306672.3 → NP_001293601.1  Calnexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLE5
      Conserved Domains (1) summary
      pfam00262
      Location:1 → 253
      Calreticulin; Calreticulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34652.1

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