OCRL OCRL, inositol polyphosphate-5-phosphatase [Gallus gallus (chicken)] - Gene

Summary

Symbol: OCRLprovided by CGNC
Full Name: OCRL, inositol polyphosphate-5-phosphataseprovided by CGNC
Primary source: CGNC:2872
See related: Ensembl:ENSGALG00010015128
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (1605060..1625053, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (1641563..1661565, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inositol polyphosphate 5-phosphatase OCRL-1; inositol polyphosphate 5-phosphatase OCRL

Names: oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphotase

XP_004940632.3

EC 3.1.3.36

XP_004940633.3

EC 3.1.3.36

XP_004940634.3

EC 3.1.3.36

XP_040525354.1

EC 3.1.3.36

XP_040525355.1

EC 3.1.3.36

XP_040525356.1

EC 3.1.3.36

XP_040525358.1

EC 3.1.3.36

XP_040525359.1

EC 3.1.3.36

XP_040555924.1

EC 3.1.3.36

XP_420138.5

EC 3.1.3.36

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1605060..1625053 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040699990.2 → XP_040555924.1 inositol polyphosphate 5-phosphatase OCRL isoform X5

Conserved Domains (3) summary

cd09093
Location:236 → 529

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:664 → 893

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 141

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_004940576.5 → XP_004940633.3 inositol polyphosphate 5-phosphatase OCRL isoform X2

Conserved Domains (3) summary

cd09093
Location:268 → 561

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:696 → 925

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 141

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_420138.8 → XP_420138.5 inositol polyphosphate 5-phosphatase OCRL isoform X4

UniProtKB/TrEMBL

A0A8V0YR87

Related

ENSGALP00010021209.1, ENSGALT00010036444.1

Conserved Domains (3) summary

cd09093
Location:237 → 530

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:665 → 894

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_004940577.5 → XP_004940634.3 inositol polyphosphate 5-phosphatase OCRL isoform X3

UniProtKB/TrEMBL

A0A8V0YXZ2

Related

ENSGALP00010021203.1, ENSGALT00010036438.1

Conserved Domains (3) summary

cd09093
Location:269 → 562

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:697 → 918

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_004940575.5 → XP_004940632.3 inositol polyphosphate 5-phosphatase OCRL isoform X1

UniProtKB/TrEMBL

A0A8V0YRC1

Related

ENSGALP00010021206.1, ENSGALT00010036441.1

Conserved Domains (3) summary

cd09093
Location:269 → 562

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:697 → 926

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

1641563..1661565 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040669425.2 → XP_040525359.1 inositol polyphosphate 5-phosphatase OCRL isoform X5

Conserved Domains (3) summary

cd09093
Location:236 → 529

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:664 → 893

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 141

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_040669421.2 → XP_040525355.1 inositol polyphosphate 5-phosphatase OCRL isoform X2

Conserved Domains (3) summary

cd09093
Location:268 → 561

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:696 → 925

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 141

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_040669424.2 → XP_040525358.1 inositol polyphosphate 5-phosphatase OCRL isoform X4

UniProtKB/TrEMBL

A0A8V0YR87

Conserved Domains (3) summary

cd09093
Location:237 → 530

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:665 → 894

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_040669422.2 → XP_040525356.1 inositol polyphosphate 5-phosphatase OCRL isoform X3

UniProtKB/TrEMBL

A0A8V0YXZ2

Conserved Domains (3) summary

cd09093
Location:269 → 562

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:697 → 918

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
XM_040669420.2 → XP_040525354.1 inositol polyphosphate 5-phosphatase OCRL isoform X1

UniProtKB/TrEMBL

A0A8V0YRC1

Conserved Domains (3) summary

cd09093
Location:269 → 562

INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins

cd04380
Location:697 → 926

RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...

cd13382
Location:44 → 142

PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain