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    GPR83 G protein-coupled receptor 83 [ Homo sapiens (human) ]

    Gene ID: 10888, updated on 11-Apr-2024

    Summary

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    Official Symbol
    GPR83provided by HGNC
    Official Full Name
    G protein-coupled receptor 83provided by HGNC
    Primary source
    HGNC:HGNC:4523
    See related
    Ensembl:ENSG00000123901 MIM:605569; AllianceGenome:HGNC:4523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIR; GPR72
    Summary
    Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within response to glucocorticoid. Located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 1.9), thyroid (RPKM 1.3) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (94377316..94401419, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (94384353..94408454, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94110482..94134585, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369435 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:93970861-93972060 Neighboring gene NANOG hESC enhancer GRCh37_chr11:93995336-93995837 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:94011033-94012232 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene NANOG hESC enhancer GRCh37_chr11:94083994-94084545 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:94113450-94113647 Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene microRNA 548l Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5403 Neighboring gene ankyrin repeat domain 49

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. Hansen W, et al. Genes Immun, 2010 Jun. PMID 20200545
    2. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. Hansen W, et al. J Immunol, 2006 Jul 1. PMID 16785516
    3. FAM237A, rather than peptide PEN and proCCK56-63, binds to and activates the orphan receptor GPR83. Li HZ, et al. FEBS J, 2023 Jul. PMID 36853120
    4. A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands. Sallee NA, et al. SLAS Discov, 2020 Oct. PMID 32713278
    5. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). De Moerlooze L, et al. Cytogenet Cell Genet, 2000. PMID 11060465

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.
      Title: A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.
    2. results suggest that the 20 additional aminoacids within GPR83 isoform-4 are involved in Treg induction during inflammatory immune responses
      Title: Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells.
    3. GPR83 is 2- to 7-fold up-regulated in all indvidual human CD4+CD25+ T regulatory cell populations analyzed and is directly linked to Foxp3 expression.
      Title: G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 83
    Names
    G-protein coupled receptor 72
    glucocorticoid induced receptor
    probable G-protein coupled receptor 83

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330345.2 → NP_001317274.1  G-protein coupled receptor 83 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AP000765
      Consensus CDS
      CCDS81616.1
      UniProtKB/TrEMBL
      Q6NWR3
      Related
      ENSP00000441550.1, ENST00000539203.2
      Conserved Domains (1) summary
      pfam00001
      Location:88 → 303
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_016540.4 → NP_057624.3  G-protein coupled receptor 83 isoform 1 precursor

      See identical proteins and their annotated locations for NP_057624.3

      Status: VALIDATED

      Source sequence(s)
      AB040973, AI914177, AK315161, AP000765, DA317535
      Consensus CDS
      CCDS8297.1
      UniProtKB/Swiss-Prot
      B0M0K5, F5GZ43, Q6NWR4, Q9NYM4, Q9P1Y8
      UniProtKB/TrEMBL
      Q6NWR3
      Related
      ENSP00000243673.2, ENST00000243673.7
      Conserved Domains (1) summary
      cd15389
      Location:72 → 356
      7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      94377316..94401419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      94384353..94408454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYM4.2 GenPept UniProtKB/Swiss-Prot:Q9NYM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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