Slc7a1 solute carrier family 7 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a1provided by RGD
Official Full Name: solute carrier family 7 member 1provided by RGD
Primary source: RGD:3716
See related: Ensembl:ENSRNOG00000000924 AllianceGenome:RGD:3716
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ERR; CAT1; EcoR; Atrc1; Cat-1
Summary: Enables L-arginine transmembrane transporter activity. Involved in L-arginine import across plasma membrane; L-arginine transmembrane transport; and regulation of TOR signaling. Located in apical plasma membrane and basal plasma membrane. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 245.3), Brain (RPKM 67.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (11664488..11740030)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (6628288..6703849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (8032775..8108972)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the presence of high-glucose levels, increased l-arginine uptake due to simvastatin treatment was associated with increased CAT-1 and eNOS mRNA levels, leading to higher NO production in immortalized rat inner blood-retinal barrier cell lines.
Title: Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).
CAT1 is involved in L-Arg uptake by retinal pericytes and this is expected to play an important role in the relaxation of retinal pericytes, thereby modulating the microcirculatory hemodynamics in the retina
Title: Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.
Aortic arginine transport by CAT-1 is attenuated in old male rats through upregulation of PKCalpha.
Title: Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats.
analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
Title: A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).
Attenuated glomerular arginine transport by CAT-1 contributes to the age-dependent, NO-deficient state in old male rats through upregulation of PKCalpha.
Title: Sexual dimorphism in glomerular arginine transport affects nitric oxide generation in old male rats.
CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor.
Title: AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
bilateral ureteral ligation as a model for obstructive uropathy induces an increase in glomerular arginine transport via upregulation of CAT-1
Title: Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats.
aortic arginine uptake is attenuated in hypercholesterolemia, through post-translational modulation of CAT-1 protein, possibly via upregulation of PKC alpha
Title: Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats.
When CAT-1-mediated transport of extracellular l-arginine into endothelial cells was suppressed, the endothelial cell NO response to a wide range of physiological stimuli was strongly depressed
Title: Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production.
transient increase in cat-1 transcription is due to transcriptional activation caused by ATF4 followed by transcriptional repression by ATF3 via a feedback mechanism.
Title: A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

AU028550 (e-PCR)
- UniSTS:112216

AU048976 (e-PCR)
- UniSTS:112216

BE113036 (e-PCR)
- UniSTS:246618

RH94683 (e-PCR)
- UniSTS:119930

D12Wox21 (e-PCR)
- UniSTS:240258

RH143690 (e-PCR)
- UniSTS:232936

BI276254 (e-PCR)
- UniSTS:249839

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-arginine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-histidine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lysine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-lysine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-lysine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-ornithine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-ornithine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-ornithine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables basic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables basic amino acid transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-arginine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-histidine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-lysine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ornithine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-ornithine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-ornithine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in basic amino acid transport	TAS Traceable Author Statement more info	PubMed
involved_in lysine transport	IEA Inferred from Electronic Annotation more info
involved_in lysine transport	ISO Inferred from Sequence Orthology more info
involved_in ornithine transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity cationic amino acid transporter 1

Names: Solute carrier family 7 member A1 (amino acid transporter cationic 1); cationic amino acid transporter, y+ system; cationinc amino acid transporter 1; ecotropic retroviral leukemia receptor; ecotropic retrovirus receptor; solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; system Y+ basic amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399982.2 → NP_001386911.1 high affinity cationic amino acid transporter 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

P70608

Related

ENSRNOP00000072647.1, ENSRNOT00000082850.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

11664488..11740030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271087.1 → XP_063127157.1 high affinity cationic amino acid transporter 1 isoform X1

UniProtKB/TrEMBL

P70608

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_013111.3: Suppressed sequence

Description

NM_013111.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.