Tmem119 transmembrane protein 119 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem119provided by MGI
Official Full Name: transmembrane protein 119provided by MGI
Primary source: MGI:MGI:2385228
See related: Ensembl:ENSMUSG00000054675 AllianceGenome:MGI:2385228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: obif
Summary: Involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Acts upstream of or within osteoblast differentiation. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skeleton. Orthologous to human TMEM119 (transmembrane protein 119). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 33.8), subcutaneous fat pad adult (RPKM 29.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (113931790..113938457, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113793729..113800396, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM119 (c.G143A, p.S48L) Mutation Is Involved in Primary Failure of Eruption by Attenuating Glycolysis-Mediated Osteogenesis.
Title: TMEM119 (c.G143A, p.S48L) Mutation Is Involved in Primary Failure of Eruption by Attenuating Glycolysis-Mediated Osteogenesis.
Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice.
Title: Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice.
Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia.
Title: Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia.
The first highly pure RNAseq profiles of microglia during development and after immune challenge show Tmem119 gene expression increases during development until P14 and then stabilizes.
Title: New tools for studying microglia in the mouse and human CNS.
Obif plays essential roles in the development of multiple tissues, is required for bone mineralization and spermatogenesis.
Title: Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice.
BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4
Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
Data show that Tmem119 promotes the differentiation of myoblasts into osteoblasts and the interaction with the BMP signaling pathway likely occurs downstream of Runx2 and Osterix in myoblasts.
Title: Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells.
Obif plays an essential role in bone formation through regulating osteoblastogenesis.
Title: OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis.
Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.
Title: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.
Study identifies a novel gene, obif (osteoblast induction factor), encoding a transmembrane protein that is predominantly expressed in osteoblasts.
Title: Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (other) (1) 1 citation
Endonuclease-mediated (10) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235267

Tmem119 (e-PCR), detects polymorphism
- UniSTS:498453

AW208946 (e-PCR)
- UniSTS:185635

Tmem119 (e-PCR), detects polymorphism
- UniSTS:498413

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 119

Names: osteoblast induction factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.