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    GHSR growth hormone secretagogue receptor [ Bos taurus (cattle) ]

    Gene ID: 514203, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GHSRprovided by VGNC
    Official Full Name
    growth hormone secretagogue receptorprovided by VGNC
    Primary source
    VGNC:VGNC:29352
    See related
    BGD:BT12745; Ensembl:ENSBTAG00000010874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GHSR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (95028001..95037403)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene TNF superfamily member 10 Neighboring gene uncharacterized LOC101905019 Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overdominance effect of the bovine ghrelin receptor (GHSR1a)-DelR242 locus on growth in Japanese Shorthorn weaner bulls: heterozygote advantage in bull selection and molecular mechanisms. Komatsu M, et al. G3 (Bethesda), 2014 Dec 23. PMID 25538099, Free PMC Article
    2. Age-related changes in gene expression of the growth hormone secretagogue and growth hormone-releasing hormone receptors in Holstein-Friesian cattle. Komatsu M, et al. Domest Anim Endocrinol, 2012 Feb. PMID 22056236
    3. Nucleotide polymorphisms and the 5'-UTR transcriptional analysis of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene. Komatsu M, et al. Anim Sci J, 2010 Oct. PMID 20887305
    4. Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism. Colinet FG, et al. Anim Biotechnol, 2009. PMID 19160085
    5. Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle. Komatsu M, et al. Anim Sci J, 2018 Feb. PMID 29154485

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GHSR1a.5'UTR-(TG)n locus plays a central role in gene-gene epistatic interaction of FA composition traits in the adipose tissue of Japanese Black cattle.
      Title: Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle.
    2. The effects of dietary energy on the metabolism of ghrelin, leptin and growth hormone secretagogue receptor in blood and tissues of steers are reported.
      Title: Circulating ghrelin and leptin concentrations and growth hormone secretagogue receptor abundance in liver, muscle, and adipose tissue of beef cattle exhibiting differences in composition of gain.
    3. The coding regions of GHSR and SLC2A2 were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2, and three were detected in GHSR.
      Title: Evaluation of polymorphisms within the genes GHSR and SLC2A2 that are within a region on bovine chromosome 1 (BTA1) previously associated with feed intake and weight gain.
    4. provided conclusive evidence that the 19-TG allele of the 5'UTR microsatellite of the bovine GHSR1a gene affects growth and carcass traits in Japanese Black cattle
      Title: Genetic association between GHSR1a 5'UTR-microsatellite and nt-7(C>A) loci and growth and carcass traits in Japanese Black cattle.
    5. We evaluated the haplotype variety and characterized the microsatellite ((TG)(n) , 5'-UTR) and nucleotide polymorphisms of the bovine GHSR1a gene.
      Title: Nucleotide polymorphisms and the 5'-UTR transcriptional analysis of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene.
    6. Six polymorphisms (five SNPs and one 3-bp indel) were identified, three of them leading to amino acid variations L24V, D194N, and Del R242.
      Title: Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth hormone secretagogue receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth hormone secretagogue receptor type 1
    Names
    growth hormone secretagogue receptor type 1B
    growth hormone secretagogue receptor type 1a-like protein
    growth hormone secretagogue receptor, type 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143736.2 → NP_001137208.1  growth hormone secretagogue receptor type 1

      See identical proteins and their annotated locations for NP_001137208.1

      Status: PROVISIONAL

      Source sequence(s)
      AB236903
      UniProtKB/TrEMBL
      B5U8Y5, C1PHZ1, C1PI23
      Related
      ENSBTAP00000014446.5, ENSBTAT00000014446.7
      Conserved Domains (1) summary
      cd15131
      Location:45 → 334
      7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95028001..95037403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010801372.3 → XP_010799674.1  growth hormone secretagogue receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_010799674.1

      UniProtKB/TrEMBL
      B5U8Y5, C1PHZ1, C1PI23
      Conserved Domains (1) summary
      cd15131
      Location:45 → 334
      7tmA_GHSR; growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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