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    Fis1 Fission, mitochondrial 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49892, updated on 10-May-2024

    Summary

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    Official Symbol
    Fis1provided by FlyBase
    Official Full Name
    Fission, mitochondrial 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039969
    Locus tag
    Dmel_CG17510
    See related
    AllianceGenome:FB:FBgn0039969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE29957; bs15a08.y1; CG17510; dFis1; Dmel\CG17510; fis1; FIS1; NEST:bs15a08
    Summary
    Involved in mitochondrion organization and positive regulation of mitochondrial fission. Predicted to be located in peroxisomal membrane. Predicted to be integral component of mitochondrial outer membrane and integral component of peroxisomal membrane. Is expressed in adult head and organism. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Fis1 in Genome Data Viewer
    Location:
    41F5-41F5; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5603587..5604834, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1491092..1492339, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene Troponin C isoform 4 Neighboring gene uncharacterized protein Neighboring gene hermes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila. Lee TT, et al. Aging Cell, 2021 Jun. PMID 34061429, Free PMC Article
    2. D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries. Debattisti V, et al. Mol Cell Neurosci, 2013 Jul. PMID 22940086
    3. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Yang Y, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18443288, Free PMC Article
    4. Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation. Chen Z, et al. J Cell Biol, 2020 Jul 6. PMID 32375181, Free PMC Article
    5. Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing. Liu B, et al. Sci Rep, 2016 Oct 11. PMID 27725692, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.
      Title: Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fission, mitochondrial 1
    Names
    CG17510-PA
    CG17510-PC
    CG17510-PD
    CG17510-PE
    CG17510-PF
    CG17510-PG
    Fis1-PA
    Fis1-PC
    Fis1-PD
    Fis1-PE
    Fis1-PF
    Fis1-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5603587..5604834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143843.4 → NP_652100.1  Fission, mitochondrial 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZT2
      Related
      FBpp0085409
      Conserved Domains (1) summary
      cl21750
      Location:1 → 64
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    2. NM_001144135.2 → NP_001137607.1  Fission, mitochondrial 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137607.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z6G3, B7YZT2, B7YZT3, Q8SYX2
      Conserved Domains (1) summary
      cd12212
      Location:9 → 120
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    3. NM_001299211.1 → NP_001286140.1  Fission, mitochondrial 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZT2
      Conserved Domains (1) summary
      cl21750
      Location:1 → 64
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    4. NM_165439.4 → NP_724420.1  Fission, mitochondrial 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZT2
      Related
      FBpp0271717
      Conserved Domains (2) summary
      cd12212
      Location:13 → 44
      Fis1; TPR repeat [structural motif]
      cl21750
      Location:1 → 64
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    5. NM_001144136.3 → NP_001137608.1  Fission, mitochondrial 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZT2
      Conserved Domains (1) summary
      cd12212
      Location:9 → 120
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    6. NM_001144137.3 → NP_001137609.1  Fission, mitochondrial 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7YZT2
      Conserved Domains (2) summary
      cd12212
      Location:13 → 44
      Fis1; TPR repeat [structural motif]
      cl21750
      Location:1 → 64
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZT2.1 B7YZT2

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