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    PLB2 lysophospholipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855018, updated on 17-May-2024

    Summary

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    Gene symbol
    PLB2
    Gene description
    lysophospholipase
    Primary source
    FungiDB:YMR006C
    Locus tag
    YMR006C
    See related
    SGD:S000004608; AllianceGenome:SGD:S000004608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophospholipase activity. Involved in glycerophospholipid metabolic process. Located in extracellular region and fungal-type cell wall. Orthologous to several human genes including JMJD7-PLA2G4B (JMJD7-PLA2G4B readthrough); PLA2G4A (phospholipase A2 group IVA); and PLA2G4D (phospholipase A2 group IVD). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PLB2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (277561..279681, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mvp1p Neighboring gene Taf4p Neighboring gene uncharacterized protein Neighboring gene lysophospholipase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Fyrst H, et al. Biochemistry, 1999 May 4. PMID 10231538
    2. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of lipid-related extracellular metabolites in Saccharomyces cerevisiae. Sun T, et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2012 May 15. PMID 22541168
    3. Ectopic expression of Arabidopsis phospholipase A genes elucidates role of phospholipase Bs in S. cerevisiae cells. Zhang M, et al. Open Microbiol J, 2009 Aug 13. PMID 19707290, Free PMC Article
    4. Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Merkel O, et al. Biochem J, 2005 Apr 15. PMID 15588231, Free PMC Article
    5. Cloning of CnLYSO1, a novel extracellular lysophospholipase of the pathogenic fungus Cryptococcus neoformans. Coe JG, et al. Gene, 2003 Oct 16. PMID 14563553

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerophospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipase
    NP_013719.1
    • Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      277561..279681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182502.1 → NP_013719.1  TPA: lysophospholipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI1, Q03674
      UniProtKB/TrEMBL
      A0A8H4F9H8, A6ZM68, N1NYL0
      Conserved Domains (1) summary
      smart00022
      Location:17 → 582
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03674.1

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