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    Acy3 aminoacylase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293653, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Acy3provided by RGD
    Official Full Name
    aminoacylase 3provided by RGD
    Primary source
    RGD:1305394
    See related
    Ensembl:ENSRNOG00000017901 AllianceGenome:RGD:1305394
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305394
    Summary
    Predicted to enable aminoacylase activity and identical protein binding activity. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in cytosol. Orthologous to human ACY3 (aminoacylase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1045.5), Liver (RPKM 89.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acy3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210709238..210715258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201279751..201285803)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219233712..219237103)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2, pseudogene 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 like 1 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene T-box transcription factor 10 Neighboring gene nudix hydrolase 8 Neighboring gene double C2-like domains, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Tsirulnikov K, et al. Toxicol Appl Pharmacol, 2012 Sep 15. PMID 22819785, Free PMC Article
    2. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. Tsirulnikov K, et al. FEBS Lett, 2012 Nov 2. PMID 23010594, Free PMC Article
    3. Structures of aminoacylase 3 in complex with acetylated substrates. Hsieh JM, et al. Proc Natl Acad Sci U S A, 2010 Oct 19. PMID 20921362, Free PMC Article
    4. Structural characterization of dimeric murine aminoacylase III. Ryazantsev S, et al. FEBS Lett, 2007 May 1. PMID 17434493
    5. Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. Pushkin A, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14656720

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we report a new potential mechanism for neuronal damage in Alzheimer disease that involves AA3; This previously unrecognized mechanism may also function in Parkinson disease
      Title: Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108859

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
    Names
    ACY-3
    aspartoacylase (aminoacylase) 3
    aspartoacylase (aminocyclase) 3
    aspartoacylase 3
    aspartoacylase-2
    NP_001009603.1
    XP_006230796.1
    XP_038964147.1
    XP_038964150.1
    XP_038964154.1
    XP_038964157.1
    XP_038964162.1
    XP_063142835.1
    XP_063142839.1
    XP_063142846.1
    XP_063142852.1
    XP_063142854.1
    XP_063142862.1
    XP_063142863.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009603.1 → NP_001009603.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

      See identical proteins and their annotated locations for NP_001009603.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088190
      UniProtKB/Swiss-Prot
      Q5M876
      UniProtKB/TrEMBL
      A6HYP7
      Related
      ENSRNOP00000024112.4, ENSRNOT00000024112.7
      Conserved Domains (1) summary
      cl11393
      Location:13 → 303
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210709238..210715258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108219.2 → XP_038964147.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

      Conserved Domains (1) summary
      cd06909
      Location:13 → 206
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    2. XM_039108234.2 → XP_038964162.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

      Conserved Domains (1) summary
      cd06909
      Location:13 → 196
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    3. XM_006230734.4 → XP_006230796.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X5

      Conserved Domains (2) summary
      pfam04952
      Location:10 → 244
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
      cl11393
      Location:13 → 249
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    4. XM_063286782.1 → XP_063142852.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X4

    5. XM_039108229.2 → XP_038964157.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

      Conserved Domains (1) summary
      cd06909
      Location:13 → 206
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    6. XM_063286792.1 → XP_063142862.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X5

    7. XM_063286776.1 → XP_063142846.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

      UniProtKB/Swiss-Prot
      Q5M876
      UniProtKB/TrEMBL
      A6HYP7

    8. XM_063286784.1 → XP_063142854.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X4

    9. XM_063286769.1 → XP_063142839.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X3

      UniProtKB/Swiss-Prot
      Q5M876
      UniProtKB/TrEMBL
      A6HYP7

    10. XM_039108226.2 → XP_038964154.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

      Conserved Domains (1) summary
      cd06909
      Location:13 → 206
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    11. XM_063286793.1 → XP_063142863.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X6

    12. XM_063286765.1 → XP_063142835.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X2

    13. XM_039108222.2 → XP_038964150.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform X1

      Conserved Domains (1) summary
      cd06909
      Location:13 → 206
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M876.1 GenPept UniProtKB/Swiss-Prot:Q5M876

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