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    CNTN1 contactin 1 [ Homo sapiens (human) ]

    Gene ID: 1272, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CNTN1provided by HGNC
    Official Full Name
    contactin 1provided by HGNC
    Primary source
    HGNC:HGNC:2171
    See related
    Ensembl:ENSG00000018236 MIM:600016; AllianceGenome:HGNC:2171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F3; GP135; MYPCN; CMYP12
    Summary
    The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in brain (RPKM 51.8), ovary (RPKM 13.6) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (40692439..41072415)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (40652132..41031590)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (41086241..41466217)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 6 pseudogene Neighboring gene MPRA-validated peak1679 silencer Neighboring gene mucin 19, oligomeric Neighboring gene NANOG hESC enhancer GRCh37_chr12:40912063-40912564 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:40959271-40960470 Neighboring gene RNA, U6 small nuclear 713, pseudogene Neighboring gene methionyl aminopeptidase 1 pseudogene Neighboring gene uncharacterized LOC124903069 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:41673681-41674880 Neighboring gene PDZ domain containing ring finger 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:41686587-41687786 Neighboring gene uncharacterized LOC107984499

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis. Fehmi J, et al. PLoS One, 2023. PMID 36893151, Free PMC Article
    2. Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis. van Lierop ZY, et al. Mult Scler, 2022 Dec. PMID 36062492, Free PMC Article
    3. Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy. Xu Q, et al. Front Immunol, 2021. PMID 34675937, Free PMC Article
    4. Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy. Le Quintrec M, et al. Kidney Int, 2021 Dec. PMID 34600965
    5. Serum Contactin-1 in CIDP: A Cross-Sectional Study. Wieske L, et al. Neurol Neuroimmunol Neuroinflamm, 2021 Jul. PMID 34285092, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
      Title: Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
    2. Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis.
      Title: Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis.
    3. The molecular mechanism of gamma-aminobutyric acid against AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2 expression.
      Title: The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression.
    4. Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis.
      Title: Neuroaxonal and Glial Markers in Patients of the Same Age With Multiple Sclerosis.
    5. Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis.
      Title: Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis.
    6. MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS.
      Title: MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS.
    7. Serum Contactin-1 in CIDP: A Cross-Sectional Study.
      Title: Serum Contactin-1 in CIDP: A Cross-Sectional Study.
    8. Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy.
      Title: Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy.
    9. Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy.
      Title: Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy.
    10. Upregulated CNTN1 is associated with lymph node metastasis and poor prognosis of colorectal cancer.
      Title: Upregulated CNTN1 is associated with lymph node metastasis and poor prognosis of colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Compton-North congenital myopathy
    MedGen: C2675527 OMIM: 612540 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese.
    EBI GWAS Catalog
    A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system myelin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-1
    Names
    glycoprotein gP135
    neural cell surface protein F3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012058.2 RefSeqGene

      Range
      4884..384860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256063.2 → NP_001242992.1  contactin-1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001242992.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
      Source sequence(s)
      AC015540, AC074030, AK289698, BC036569, DQ442054
      Consensus CDS
      CCDS58225.1
      UniProtKB/Swiss-Prot
      Q12860
      Related
      ENSP00000448004.1, ENST00000547702.5
      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 602
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    2. NM_001256064.2 → NP_001242993.1  contactin-1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001242993.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks several 3' exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
      Source sequence(s)
      AC015540, AK289544
      Consensus CDS
      CCDS58225.1
      UniProtKB/Swiss-Prot
      Q12860
      Related
      ENSP00000448653.1, ENST00000547849.6
      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 602
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    3. NM_001843.4 → NP_001834.2  contactin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001834.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC024900, AC074030, AI473107, AK289698, BM717031, BX648591, BY799936, DQ442054, U07819, Z21488
      Consensus CDS
      CCDS8737.1
      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466
      Related
      ENSP00000447006.1, ENST00000551295.7
      Conserved Domains (10) summary
      cd04970
      Location:520 → 601
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:422 → 501
      IG_like; Immunoglobulin like
      cd00063
      Location:610 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:331 → 408
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:811 → 893
      fn3; Fibronectin type III domain
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    4. NM_175038.2 → NP_778203.1  contactin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_778203.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region, compared to isoform 1.
      Source sequence(s)
      AI473107, BC036569, BM717031, BX648591, BY799936, U07820
      Consensus CDS
      CCDS8738.1
      UniProtKB/Swiss-Prot
      Q12860
      Related
      ENSP00000261160.3, ENST00000348761.2
      Conserved Domains (10) summary
      cd04970
      Location:509 → 590
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:123 → 219
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:29 → 121
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:230 → 317
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:418 → 490
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:411 → 490
      IG_like; Immunoglobulin like
      cd00063
      Location:599 → 686
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:320 → 397
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:800 → 882
      fn3; Fibronectin type III domain
      cl11960
      Location:321 → 397
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      40692439..41072415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537926.4 → XP_011536228.1  contactin-1 isoform X1

      See identical proteins and their annotated locations for XP_011536228.1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466
      Conserved Domains (10) summary
      cd04970
      Location:520 → 601
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:422 → 501
      IG_like; Immunoglobulin like
      cd00063
      Location:610 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:331 → 408
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:811 → 893
      fn3; Fibronectin type III domain
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    2. XM_024448843.2 → XP_024304611.1  contactin-1 isoform X2

      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 602
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    3. XM_005268651.3 → XP_005268708.1  contactin-1 isoform X1

      See identical proteins and their annotated locations for XP_005268708.1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466
      Related
      ENSP00000325660.3, ENST00000347616.5
      Conserved Domains (10) summary
      cd04970
      Location:520 → 601
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:422 → 501
      IG_like; Immunoglobulin like
      cd00063
      Location:610 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:331 → 408
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:811 → 893
      fn3; Fibronectin type III domain
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    4. XM_011537927.3 → XP_011536229.1  contactin-1 isoform X1

      See identical proteins and their annotated locations for XP_011536229.1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466
      Conserved Domains (10) summary
      cd04970
      Location:520 → 601
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:422 → 501
      IG_like; Immunoglobulin like
      cd00063
      Location:610 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:331 → 408
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:811 → 893
      fn3; Fibronectin type III domain
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    5. XM_006719241.3 → XP_006719304.1  contactin-1 isoform X1

      See identical proteins and their annotated locations for XP_006719304.1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466
      Conserved Domains (10) summary
      cd04970
      Location:520 → 601
      Ig6_Contactin_like; Sixth Ig domain of contactin
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First Ig domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third Ig domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth Ig domain of contactin-1
      smart00410
      Location:422 → 501
      IG_like; Immunoglobulin like
      cd00063
      Location:610 → 697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:331 → 408
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:811 → 893
      fn3; Fibronectin type III domain
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    6. XM_017018827.3 → XP_016874316.1  contactin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q12860
      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 602
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    7. XM_017018826.3 → XP_016874315.1  contactin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q12860
      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 602
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      40652132..41031590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371130.1 → XP_054227105.1  contactin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466

    2. XM_054371133.1 → XP_054227108.1  contactin-1 isoform X2

    3. XM_054371131.1 → XP_054227106.1  contactin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466

    4. XM_054371132.1 → XP_054227107.1  contactin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466

    5. XM_054371129.1 → XP_054227104.1  contactin-1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0H9, A8K0Y3, Q12860, Q12861, Q14030, Q7M4P0, Q8N466

    6. XM_054371135.1 → XP_054227110.1  contactin-1 isoform X2

    7. XM_054371134.1 → XP_054227109.1  contactin-1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12860.1 GenPept UniProtKB/Swiss-Prot:Q12860

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