su(Hw) suppressor of Hairy wing [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: su(Hw)provided by FlyBase
Official Full Name: suppressor of Hairy wingprovided by FlyBase
Primary source: FLYBASE:FBgn0003567
Locus tag: Dmel_CG8573
See related: AllianceGenome:FB:FBgn0003567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8573; Dmel\CG8573; su(hw); su(HW); Su(hw); Su(Hw); Su(HW); SU(HW); suHw; SUHW; Su[Hw]
Summary: Enables chromatin insulator sequence binding activity; euchromatin binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of macromolecule metabolic process; protein localization to euchromatin; and response to ecdysone. Located in chromatin; nucleus; and polytene chromosome. Is expressed in several structures, including central nervous system; extended germ band embryo; female-specific anatomical entity; germ layer; and gut section. Orthologous to human ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 88B3-88B3; 3-55 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14304455..14308589, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10130177..10134311, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
Title: A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
Title: M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
Title: HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.
Title: Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding.
Study highlights that Su(Hw) has a major developmental function as a transcriptional repressor, with the effect of its loss dependent upon the cell-specific factors.
Title: Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells of Drosophila.
the role of the Su(Hw) protein in Drosophila oogenesis as a transcription repressor
Title: Insulator Protein Su(Hw) Is Indispensable for Amplification of Part of Drosophila Amplicons in Follicular Cells (DAFCs) during Early Oogenesis.
Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila
Title: Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila.
Su(Hw) genomic sites separate into sequence subclasses comprised of combinations of modules, with subclasses enriched for different chromatin features.
Title: Deciphering the DNA code for the function of the Drosophila polydactyl zinc finger protein Suppressor of Hairy-wing.
Study of the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators; demonstrated that the Su(Hw) protein zinc finger domain is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein
Title: Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex.
It was demonstrated that the interaction of Su(Hw) and Mod(mdg4)-67.2 insulator proteins with the terminator regions of the selected genes was dependent on the Su(Hw) factor.
Title: [The Role of Su(Hw) Protein in Transcription Regulation in Drosophila melanogaster].

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables euchromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heterochromatin boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to euchromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ecdysone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: suppressor of hairy wing

Names: CG8573-PA; CG8573-PB; CG8573-PC; su(Hw)-PA; su(Hw)-PB; su(Hw)-PC; suppressor of Hair-Wing; suppressor of hairy-wing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14304455..14308589 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079625.3 → NP_524349.1 suppressor of hairy wing, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524349.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08970, Q0KI74, Q9VFK9

UniProtKB/TrEMBL

A0A0B4K6W1

Related

FBpp0082405

Conserved Domains (5) summary

COG5048
Location:312 → 517

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:443 → 463

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:598 → 615

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:348 → 368

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:484 → 508

zf-H2C2_2; Zinc-finger double domain
NM_169574.2 → NP_731897.1 suppressor of hairy wing, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731897.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08970, Q0KI74, Q9VFK9

UniProtKB/TrEMBL

A0A0B4K6W1

Related

FBpp0082404

Conserved Domains (5) summary

COG5048
Location:312 → 517

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:443 → 463

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:598 → 615

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:348 → 368

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:484 → 508

zf-H2C2_2; Zinc-finger double domain
NM_001260169.2 → NP_001247098.1 suppressor of hairy wing, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247098.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08970, Q0KI74, Q9VFK9

UniProtKB/TrEMBL

A0A0B4K6W1

Conserved Domains (5) summary

COG5048
Location:312 → 517

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:443 → 463

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:598 → 615

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:348 → 368

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:484 → 508

zf-H2C2_2; Zinc-finger double domain