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    PGRP-SB2 Peptidoglycan recognition protein SB2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39869, updated on 10-May-2024

    Summary

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    Official Symbol
    PGRP-SB2provided by FlyBase
    Official Full Name
    Peptidoglycan recognition protein SB2provided by FlyBase
    Primary source
    FLYBASE:FBgn0043577
    Locus tag
    Dmel_CG9697
    See related
    AllianceGenome:FB:FBgn0043577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9697; Dmel\CG9697; PGRP-SB
    Summary
    Predicted to enable N-acetylmuramoyl-L-alanine amidase activity. Predicted to be involved in peptidoglycan catabolic process. Located in extracellular region. Orthologous to several human genes including PGLYRP1 (peptidoglycan recognition protein 1); PGLYRP2 (peptidoglycan recognition protein 2); and PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PGRP-SB2 in Genome Data Viewer
    Location:
    73C1-73C1; 3-44 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16726541..16727288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16719641..16720388)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Disabled Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SB1 Neighboring gene Dead box protein 73D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance. Musselman LP, et al. Mol Cell Biol, 2018 Jan 15. PMID 29084810, Free PMC Article
    2. Peptidoglycan recognition proteins in hematophagous arthropods. Wang J, et al. Dev Comp Immunol, 2018 Jun. PMID 29269264, Free PMC Article
    3. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Paredes JC, et al. Immunity, 2011 Nov 23. PMID 22118526
    4. Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. Zaidman-Rémy A, et al. PLoS One, 2011 Feb 18. PMID 21364998, Free PMC Article
    5. The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins. Jiggins FM, et al. J Mol Evol, 2003 Nov. PMID 14738318, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylmuramoyl-L-alanine amidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan recognition protein SB2
    Names
    CG9697-PA
    CG9697-PB
    PGRP-SB2-PA
    PGRP-SB2-PB
    NP_001261970.1
    NP_648916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16726541..16727288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140659.3 → NP_648916.1  peptidoglycan recognition protein SB2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q70PX1, Q70PX3, Q70PX5, Q9VV96
      UniProtKB/TrEMBL
      C9QNY3
      Related
      FBpp0075079
      Conserved Domains (1) summary
      smart00701
      Location:18 → 158
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    2. NM_001275041.1 → NP_001261970.1  peptidoglycan recognition protein SB2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFJ1
      Conserved Domains (1) summary
      smart00701
      Location:18 → 129
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFJ1 M9PFJ1
    Q9VV96.1 Q9VV96

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