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    Cul2 cullin 2 [ Mus musculus (house mouse) ]

    Gene ID: 71745, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cul2provided by MGI
    Official Full Name
    cullin 2provided by MGI
    Primary source
    MGI:MGI:1918995
    See related
    Ensembl:ENSMUSG00000024231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI327301; mKIAA4106; 1300003D18Rik; 4932411N15Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cul2 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3382970..3436700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3382970..3436700)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (3383223..3436698)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene cAMP responsive element modulator Neighboring gene predicted gene 6225 Neighboring gene profilin 1 pseudogene Neighboring gene BMP and activin membrane-bound inhibitor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4106

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360829.1NP_001347758.1  cullin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124336
      Consensus CDS
      CCDS29032.2
      Related
      ENSMUSP00000025073.6, ENSMUST00000025073.12
      Conserved Domains (2) summary
      pfam00888
      Location:14644
      Cullin; Cullin family
      pfam10557
      Location:677735
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_029402.3NP_083678.2  cullin-2

      See identical proteins and their annotated locations for NP_083678.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124336, AK004875, AK144693, AK162910
      Consensus CDS
      CCDS29032.2
      UniProtKB/Swiss-Prot
      Q9D4H8
      Related
      ENSMUSP00000125403.2, ENSMUST00000162301.8
      Conserved Domains (2) summary
      pfam00888
      Location:14644
      Cullin; Cullin family
      pfam10557
      Location:677735
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      3382970..3436700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526275.5XP_006526338.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_006526338.1

      UniProtKB/Swiss-Prot
      Q9D4H8
      Conserved Domains (2) summary
      pfam00888
      Location:14644
      Cullin; Cullin family
      pfam10557
      Location:677735
      Cullin_Nedd8; Cullin protein neddylation domain
    2. XM_030250610.2XP_030106470.1  cullin-2 isoform X1

      Conserved Domains (2) summary
      pfam00888
      Location:14644
      Cullin; Cullin family
      pfam10557
      Location:677735
      Cullin_Nedd8; Cullin protein neddylation domain
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